Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults.
Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults.
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DOI：
10.1038/s41598-020-76160-9
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发表时间：
2020-11-24
影响因子：
4.6
通讯作者：
Rendeiro C
中科院分区：
文献类型：
--
作者：
Gratton G;Weaver SR;Burley CV;Low KA;Maclin EL;Johns PW;Pham QS;Lucas SJE;Fabiani M;Rendeiro C
可可黄烷醇保护人类免受血管疾病，如外周内皮功能的改善所证明的，可能通过一氧化氮信号传导。新出现的证据也表明，富含黄烷醇的饮食可以防止认知老化，但机制仍然难以捉摸。在一项对健康年轻人进行的随机双盲受试者内急性研究中，我们首次将这两条研究线联系起来，表明黄烷醇摄入导致对高碳酸血症的更快和更大的脑氧合反应，以及只有在认知需求高时才有更高的表现。个体差异分析进一步表明，在高碳酸血症期间从黄烷醇摄入中获益的参与者也是在认知挑战中获益的参与者。这些数据支持的假设，类似的血管机制的基础外周和大脑的黄烷醇的影响。他们进一步表明，结合年轻人的生理和分级认知挑战来研究饮食黄烷醇对大脑功能的作用的重要性。
Cocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence also suggests that flavanol-rich diets protect against cognitive aging, but mechanisms remain elusive. In a randomized double-blind within-subject acute study in healthy young adults, we link these two lines of research by showing, for the first time, that flavanol intake leads to faster and greater brain oxygenation responses to hypercapnia, as well as higher performance only when cognitive demand is high. Individual difference analyses further show that participants who benefit from flavanols intake during hypercapnia are also those who do so in the cognitive challenge. These data support the hypothesis that similar vascular mechanisms underlie both the peripheral and cerebral effects of flavanols. They further show the importance of studies combining physiological and graded cognitive challenges in young adults to investigate the actions of dietary flavanols on brain function.
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影响因子：
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