Increased germ cell degeneration during postprophase of meiosis is related to increased serum follicle-stimulating hormone concentrations and reduced daily sperm production in aged men.
Increased germ cell degeneration during postprophase of meiosis is related to increased serum follicle-stimulating hormone concentrations and reduced daily sperm production in aged men.
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减数分裂前期生殖细胞退化的增加与老年男性血清促卵泡激素浓度的增加和每日精子产量的减少有关。
DOI：
10.1095/biolreprod42.2.281
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发表时间：
1990
影响因子：
3.6
通讯作者：
Petty,CS
中科院分区：
文献类型：
--
作者：
Johnson,L;Grumbles,JS;Bagheri,A;Petty,CS
已知老年男性血清促性腺激素水平高，生精潜力降低，研究血清促卵泡激素（FSH）与生殖细胞变性之间的关系。从尸检时获得的血液中测量血清激素。采用相衬细胞术对13名年轻男性（24-51岁）和14名老年男性（69-90岁）固定睾丸匀浆中的生殖细胞进行计数。通过比较基于初级精子细胞的每日精子产量和基于两种不同类型精子的每日精子产量，确定了生殖细胞退化的精子发生发育步骤。在精子发生过程中，年轻男性和老年男性没有明显的退化。在减数分裂前期后期，老年男性生殖细胞变性发生率（p< 0.01）高于年轻男性（p< 0.01），血清睾酮显著降低（p< 0.01），血清FSH显著升高（p< 0.01）。减数分裂前期后期生殖细胞退化与每日精子产量呈负相关（p< 0.01），与血清FSH浓度显著相关（p< 0.01）。在这些老年男性中发现，减数分裂生殖细胞退化对每日精子产量有直接影响，并与血清FSH浓度显著相关。
Aged men, known to have high serum gonadotropin levels and reduced spermatogenic potential, were used to study the relationship between serum follicle-stimulating hormone(FSH) and germ cell degeneration. Serum hormones were measured from blood obtained at autopsy. Phase-contrast cytometry was used to enumerate germ cells in homogenates of fixed testes from 13 younger(24-51 yr) and 14 aged (69-90 yr) men. The developmental steps of spermatogenesis during which germ cells degenerate were determined by comparing potential daily sperm production based on primary spermatocytes with daily sperm production based on two different types of spermasids. During spermiogenesis, there was no significant degeneration in the younger or aged men. During postprophase of meiosis, aged men had more(p< O. Ol) germ cell degeneration, significantly lower (p< O. O5) serum testosterone, and greater(p< O. OI) serum FSH than did younger men. Germ cell degeneration during postprophase of meiosis was negatively correlated(p< O. 0l): o daily sperm production and significantly(p< O. Ol) related to serum concentrations of FSH. As revealed in these aged men, meiotic germ cell degeneration has a direct effect on daily sperm production and is significantly related to serum FSH concentrations.
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年龄、饮酒量和体型对男性性腺功能的影响。
影响因子：
5.8
作者：
D. Sparrow;R. Bossé;J. Rowe
通讯作者：
J. Rowe
影响因子：
5.8
作者：
NEAVES, WB;JOHNSON, L;PETTY, CS
通讯作者：
PETTY, CS
人类精子发生过程中生殖细胞的损失。
DOI：
--
发表时间：
1971
期刊：
影响因子：
--
作者：
Barr Ab;Mooré Dj;Paulsen Ca
通讯作者：
Paulsen Ca
男性不育症生殖细胞与血清FSH水平的关系。
影响因子：
5.8
作者：
D. de Kretser;H. Burger;B. Hudson
通讯作者：
B. Hudson