Reductions in human Lyme disease risk due to the effects of oral vaccination on tick-to-mouse and mouse-to-tick transmission.
Reductions in human Lyme disease risk due to the effects of oral vaccination on tick-to-mouse and mouse-to-tick transmission.
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由于口服疫苗对蜱到小鼠和小鼠到蜱传播的影响，降低了人类莱姆病的风险。
DOI：
10.1089/vbz.2012.1003
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Brisson,Dustin
中科院分区：
文献类型：
--
作者：
Voordouw,MaartenJ;Tupper,Haley;Önder,Özlem;Devevey,Godefroy;Graves,ChristopherJ;Kemps,BrianD;Brisson,Dustin
Vaccinating wildlife is becoming an increasingly popular method to reduce human disease risks from pathogens such asBorrelia burgdorferi,the causative agent of Lyme disease. To successfully limit human disease risk, vaccines targeting the wildlife reservoirs ofB. burgdorferimust be easily distributable and must effectively reduce pathogen transmission from infected animals, given that many animals in nature will be infected prior to vaccination. We assessed the efficacy of an easily distributable oral bait vaccine based on the immunogenic outer surface protein A (OspA) to protect uninfected mice from infection and to reduce transmission from previously infected white-footed mice, an important reservoir host ofB. burgdorferi. Oral vaccination of white-footed mice effectively reduces transmission ofB. burgdorferiat both critical stages of the Lyme disease transmission cycle. First, oral vaccination of uninfected white-footed mice elicits an immune response that protects mice fromB. burgdorferiinfection. Second, oral vaccination of previously infected mice significantly reduces the transmission ofB. burgdorferito feeding ticks despite a statistically nonsignificant immune response. We used the estimates of pathogen transmission to and from vaccinated and unvaccinated mice to model the efficacy of an oral vaccination campaign targeting wild white-footed mice. Projection models suggest that the effects of the vaccine on both critical stages of the transmission cycle ofB. burgdorferiact synergistically in a positive feedback loop to reduce the nymphal infection prevalence, and thus human Lyme disease risk, well below what would be expected from either effect alone. This study suggests that oral immunization of wildlife with an OspA-based vaccine can be a promising long-term strategy to reduce human Lyme disease risk.
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影响因子：
158.5
作者：
Rupprecht, CE;Blass, L;Hanlon, CA
通讯作者：
Hanlon, CA
DOI：
10.1098/rspb.2009.0414
发表时间：
2009-08-22
影响因子：
4.7
作者：
Tompkins, D. M.;Ramsey, D. S. L.;Buddle, B. M.
通讯作者：
Buddle, B. M.
伯氏疏螺旋体对莱姆病储存宿主白鼠白鼠 (Peromyscus leucopus) 的影响极小。
DOI：
--
发表时间：
2011
期刊：
Vector Borne and Zoonotic Diseases
影响因子：
--
作者：
L. Schwanz;M. Voordouw;Dustin Brisson;R. Ostfeld
通讯作者：
R. Ostfeld
DOI：
10.4269/ajtmh.2012.11-0395
发表时间：
2012-02-01
影响因子：
3.3
作者：
Diuk-Wasser, Maria A.;Hoen, Anne Gatewood;Fish, Durland
通讯作者：
Fish, Durland
人类接触含有控制野生动物狂犬病疫苗的诱饵。
DOI：
10.2460/javma.1998.213.10.1413
发表时间：
1998
期刊：
Journal of the American Veterinary Medical Association
影响因子：
--
作者：
Michael W. McGuill;Silvia M. Kreindel;Alfred DeMaria;Alison H. Robbins;Steven Rowell;Cathleen A. Hanlon;Charles E. Rupprecht
通讯作者：
Charles E. Rupprecht