Clinical characteristics and survival of lung cancer patients associated with multiple primary malignancies.
Clinical characteristics and survival of lung cancer patients associated with multiple primary malignancies.
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多种原发性恶性肿瘤相关肺癌患者的临床特征和生存率
DOI：
10.1371/journal.pone.0185485
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wu FY
中科院分区：
文献类型：
--
作者：
Shan S;She J;Xue ZQ;Su CX;Ren SX;Wu FY
研究合并恶性原发癌的肺癌患者的特征和生存率。
回顾性分析2000年1月至2010年1月期间在上海市肺科医院新确诊的肺癌患者的病历。详细分析包括第二原发性肺癌患者和仅有肺癌的患者。
在 27642 名新确诊的肺癌患者中，有 283 名患者（1.02%）曾患有其他原发性癌症。与单原发性肺癌相比，伴有其他原发性癌症的继发性肺癌患者多为女性（男女比例为 1:1.72 vs 1:2.58，P = 0.018），年龄更大（64.2 vs 60.5 岁，P<0.001）、鳞状细胞类型较多（30.7% 对 20.5%，P = 0.004）、小细胞类型较少（3.9% 对 15.5%，P<0.001）、分期较早（17.7% 对 11.0% 为 I 期，P = 0.014）、有癌症家族史的较多（7.8% 对 3.9%，P = 0.038）。最常见的原发性癌症是结直肠癌（22.0%）、乳腺癌（18.4%）、胃癌（14.4%）和喉癌（11.9%）。约42.9%的患者在确诊原发性癌症2至6年后被诊断为肺癌。与单发肺癌患者相比，伴有其他恶性肿瘤的继发性肺癌患者的生存率并无明显差异（P = 0.491），而同步多发性原发性恶性肿瘤患者的预后要差于间变性原发性恶性肿瘤或单发肺癌患者（P = 0.012）。
在对相关癌症类型，尤其是有癌症家族史的癌症类型进行随访时，应始终考虑第二原发性肺癌的可能性。与其他原发性恶性肿瘤相关的继发性肺癌患者的生存率并不比单发肺癌患者低。
Objectives To investigate the characteristics and survival of lung cancer patients with additional malignant primary cancers. Methods Records of lung cancer patients newly diagnosed in Shanghai Pulmonary Hospital between January 2000 and January 2010 were retrospectively reviewed. Patients with second primary lung cancer and those with lung cancer only were included for detailed analysis. Results Of 27642 newly diagnosed lung cancer patients, 283 patients (1.02%) suffered previous additional primary cancers. Compared with single primary lung cancer, patients with secondary lung cancer associated other primary cancers were more often women (female to male ratio 1:1.72 vs 1:2.58, P = 0.018), older (64.2 vs 60.5 years old, P<0.001), more squamous cell type (30.7% vs 20.5%, P = 0.004), less small cell (3.9% vs 15.5%, P<0.001) type, at earlier stages (17.7% vs 11.0% for stage I, P = 0.014), and more frequently with family history of cancers (7.8% vs 3.9%, P = 0.038). The most common previous primary cancers observed were colorectal (22.0%), breast (18.4%), gastric (14.4%) and larynx cancers (11.9%). Approximately 42.9% of patients were diagnosed with lung cancer 2 to 6 years after diagnosis of initial primary cancers. The survival of patients with secondary lung cancer associated other malignancies was not significantly different from those with single lung cancer (P = 0.491), while synchronous multiple primary malignancies showed worse prognosis compared with those with metachronous ones or single lung cancer (p = 0.012). Conclusion The possibility of second primary lung cancer should always be considered during the follow-up of related cancer types, especially those with family history of cancers. Patients with secondary lung cancer associated other primary malignancies have non-inferior survival than those with single lung cancer.
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影响因子：
1.7
作者：
Hemminki, K;Li, XJ
通讯作者：
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DOI：
10.1200/jco.2007.13.2654
发表时间：
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期刊：
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影响因子：
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作者：
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DOI：
10.1002/hed.22006
发表时间：
2012-12-01
影响因子：
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作者：
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作者：
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