Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders.
Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders.
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DOI：
10.1016/j.psychres.2017.08.058
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发表时间：
2017-12
影响因子：
11.3
通讯作者：
Levy I
中科院分区：
文献类型：
--
作者：
Pushkarskaya H;Tolin D;Ruderman L;Henick D;Kelly JM;Pittenger C;Levy I
决策困难是一系列疾病状态的核心损害。例如，强迫症（OCD）和囤积症（HD）都与优柔寡断、计划效率低下和不确定性耐受性增强有关，即使在与其核心症状无关的情况下也是如此。我们研究了19名强迫症患者、19名强迫症患者、19名强迫症合并强迫症患者和57名普通人群的决策模式，采用了基于行为经济学理论的有效选择任务。我们的研究结果表明，强迫症患者（有或没有共病HD）的决策困难与基于价值的决策的保真度降低有关（即增加不一致的选择）。相比之下，我们发现HD患者在实验室任务中的表现基本完好无损。总的来说，这些结果支持了我们的假设，即强迫症和多动症的决策障碍在临床上看起来非常相似，但其基础却有重要的不同。系统调查决策的不同方面，在不同的条件下，可能会对临床综合征之间的共性和区别有新的认识。
Difficulties in decision making are a core impairment in a range of disease states. For instance, both obsessive-compulsive disorder (OCD) and hoarding disorder (HD) are associated with indecisiveness, inefficient planning, and enhanced uncertainty intolerance, even in contexts unrelated to their core symptomology. We examined decision-making patterns in 19 individuals with OCD, 19 individuals with HD, 19 individuals with comorbid OCD and HD, and 57 individuals from the general population, using a well-validated choice task grounded in behavioral economic theory. Our results suggest that difficulties in decision making in individuals with OCD (with or without comorbid HD) are linked to reduced fidelity of value-based decision making (i.e. increase in inconsistent choices). In contrast, we find that performance of individuals with HD on our laboratory task is largely intact. Overall, these results support our hypothesis that decision-making impairments in OCD and HD, which can appear quite similar clinically, have importantly different underpinnings. Systematic investigation of different aspects of decision making, under varying conditions, may shed new light on commonalities between and distinctions among clinical syndromes.
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影响因子：
7.4
作者：
Frost, Randy O.;Steketee, Gail;Tolin, David F.
通讯作者：
Tolin, David F.
影响因子：
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作者：
Banca, Paula;Vestergaard, Martin D.;Rankov, Vladan;Baek, Kwangyeol;Mitchell, Simon;Lapa, Tatyana;Castelo-Branco, Miguel;Voon, Valerie
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Voon, Valerie
影响因子：
4.1
作者：
Frost, RO;Steketee, G;Grisham, J
通讯作者：
Grisham, J
影响因子：
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作者：
FOA, EB;ILAI, D;MURDOCK, T
通讯作者：
MURDOCK, T
影响因子：
2.5
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da Rocha, F. F.;Malloy-Diniz, L.;Correa, H.
通讯作者：
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