Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.
Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.
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DOI：
10.3390/molecules14072373
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发表时间：
2009-07-03
期刊：
影响因子：
--
通讯作者：
Palazón J
中科院分区：
文献类型：
--
作者：
Mirjalili MH;Moyano E;Bonfill M;Cusido RM;Palazón J
Withania somnifera，通常被称为Ashwagandha，是一种重要的药用植物，已被用于阿育吠陀和土著医学超过3,000年。鉴于其各种治疗潜力，它也一直是现代科学关注的主题。睡茄属的主要化学成分睡茄内酯是一组天然存在的C28-甾体内酯三萜类化合物，其构建在完整或重排的麦角甾烷框架上，其中C-22和C-26被适当氧化以形成六元内酯环。近年来，对W.睡莲提取物我们在这里提出的三萜类成分的化学结构和它们的生物活性的概述，集中在两个新的活动，肿瘤抑制和抗血管生成特性的withaferin A和withantera A对阿尔茨海默病的影响。最新的尝试在生物技术生产的睡茄内酯进行了讨论。
Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The major chemical constituents of the Withania genus, the withanolides, are a group of naturally occurring C28-steroidal lactone triterpenoids built on an intact or rearranged ergostane framework, in which C-22 and C-26 are appropriately oxidized to form a six-membered lactone ring. In recent years, numerous pharmacological investigations have been carried out into the components of W. somnifera extracts. We present here an overview of the chemical structures of triterpenoid components and their biological activity, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease. The most recent attempts in biotechnological production of withanolides are also discussed.
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影响因子：
4.1
作者：
Bonhomme, V;Laurain-Mattar, D;Jacquin-Dubreuil, A
通讯作者：
Jacquin-Dubreuil, A
影响因子：
7.2
作者：
BANERJEE, S;NAQVI, AA;AHUJA, PS
通讯作者：
AHUJA, PS
影响因子：
6.2
作者：
Bandyopadhyay, Maumita;Jha, Sumita;Tepfer, David
通讯作者：
Tepfer, David
影响因子：
3.6
作者：
Bhattacharya, SK;Muruganandam, AV
通讯作者：
Muruganandam, AV
影响因子：
5.1
作者：
Bonhomme, V;Laurain-Mattar, D;Fliniaux, MA
通讯作者：
Fliniaux, MA