Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review.
Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review.
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DOI：
10.3390/ijerph18084079
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发表时间：
2021-04-13
影响因子：
--
通讯作者：
Pérez-Rubio G
中科院分区：
文献类型：
--
作者：
Bravo-Gutiérrez OA;Falfán-Valencia R;Ramírez-Venegas A;Sansores RH;Ponciano-Rodríguez G;Pérez-Rubio G
烟草业推广电子尼古丁输送系统 (ENDS) 和加热烟草产品 (HTP) 作为传统卷烟的更安全替代品，并通过利益冲突研究维持误导性营销。因此，这些设备在销售时没有任何监管规定，也没有关于其对健康产生不利影响的警告，而且针对年轻人的用户群不断增长。本系统综述旨在描述这些设备对消费者呼吸系统的不利影响。我们对 79 项无利益冲突的研究进行了系统回顾和文献计量分析，评估实验模型中 ENDS 和 HTP 对呼吸系统的影响，这些研究是从 PubMed 数据库检索的。我们发现，使用这些设备产生的损害涉及与肺部疾病相关的途径，涉及先前在传统卷烟中报道的机制以及这些设备特有的新机制，这对烟草业的说法提出了挑战。本研究提供了重要的证据表明这些设备是一个新出现的公共卫生问题，应该对其进行监管或避免。
The tobacco industry promotes electronic nicotine delivery systems (ENDS) and heated tobacco products (HTP) as a safer alternative to conventional cigarettes with misleading marketing sustained by studies with conflict of interest. As a result, these devices sell without regulations and warnings about their adverse effects on health, with a growing user base targeting young people. This systematic review aimed to describe the adverse effects on the respiratory system in consumers of these devices. We conducted a systematic review and bibliometric analysis of 79 studies without conflict of interest evaluating ENDS and HTP effects in the respiratory system in experimental models, retrieved from the PubMed database. We found that the damage produced by using these devices is involved in pathways related to pulmonary diseases, involving mechanisms previously reported in conventional cigarettes as well as new mechanisms particular to these devices, which challenges that the tobacco industry’s claims. The present study provides significant evidence to suggest that these devices are an emerging public health problem and that they should be regulated or avoided.
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影响因子：
3.7
作者：
Gomez, Andromeda-Celeste;Rodriguez-Fernandez, Pablo;Dominguez, Jose
通讯作者：
Dominguez, Jose
影响因子：
3.4
作者：
Cirillo, Silvia;Urena, Jose F.;Elias, Ryan J.
通讯作者：
Elias, Ryan J.
影响因子：
13.6
作者：
Dusautoir, Romain;Zarcone, Gianni;Antherieu, Sebastien
通讯作者：
Antherieu, Sebastien
影响因子：
5
作者：
Chen L;Arens R;Chidambaram AG;Capponi S;Alshawa L;Claeys TA;Hayes D Jr;Robinson RT
通讯作者：
Robinson RT
影响因子：
--
作者：
Gerloff J;Sundar IK;Freter R;Sekera ER;Friedman AE;Robinson R;Pagano T;Rahman I
通讯作者：
Rahman I