Development and evaluation of dose calculation algorithm with a combination of Monte Carlo and point-kernel methods for boron neutron capture therapy
Development and evaluation of dose calculation algorithm with a combination of Monte Carlo and point-kernel methods for boron neutron capture therapy
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结合蒙特卡罗和点核方法的硼中子俘获治疗剂量计算算法的开发和评估
DOI：
10.1088/2057-1976/acc33c
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Tanaka Hiroki
中科院分区：
文献类型：
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作者：
Nojiri Mai;Takata Takushi;Hu Naonori;Sakurai Yoshinori;Suzuki Minoru;Tanaka Hiroki
我们开发了一种“混合算法”，结合蒙特卡罗（MC）和点核方法的快速剂量计算硼中子俘获治疗。本研究的目的是实验验证的混合算法，并验证的计算精度和时间的一个“互补的方法”，采用混合算法和全能量MC方法。在后者的验证中，将结果与单独使用全能量MC方法获得的结果进行了比较。在混合算法中，中子的慢化过程只用MC方法模拟，热化过程作为一个核心模型。仅使用该算法计算的热中子通量进行了比较，在一个立方体模测量。此外，在模拟头部区域的几何结构中使用补充方法进行剂量计算，并验证了其计算时间和精度。实验验证表明，仅使用混合算法计算的热中子通量在深度超过几厘米时再现了测量值，而在较浅的深度时则高估了测量值。与仅使用全能量MC方法的计算相比，互补方法的计算时间减少了大约一半，保持几乎相同的精度。当仅针对热中子反应引起的硼剂量仅使用混合算法进行计算时，与仅使用全能MC方法的计算相比，预计计算时间减少95%。总之，将热化过程作为核心来建模，对于减少计算时间是有效的。
We developed a'hybrid algorithm'that combines the Monte Carlo (MC) and point-kernel methods for fast dose calculation in boron neutron capture therapy. The objectives of this study were to experimentally verify the hybrid algorithm and to verify the calculation accuracy and time of a'complementary approach'adopting both the hybrid algorithm and the full-energy MC method. In the latter verification, the results were compared with those obtained using the full-energy MC method alone. In the hybrid algorithm, the moderation process of neutrons is simulated using only the MC method, and the thermalization process is modeled as a kernel. The thermal neutron fluxes calculated using only this algorithm were compared with those measured in a cubic phantom. In addition, a complementary approach was used for dose calculation in a geometry simulating the head region, and its computation time and accuracy were verified. The experimental verification indicated that the thermal neutron fluxes calculated using only the hybrid algorithm reproduced the measured values at depths exceeding a few centimeters, whereas they overestimated those at shallower depths. Compared with the calculation using only the full-energy MC method, the complementary approach reduced the computation time by approximately half, maintaining nearly same accuracy. When focusing on the calculation only using the hybrid algorithm only for the boron dose attributed to the reaction of thermal neutrons, the computation time was expected to reduce by 95% compared with the calculation using only the full-energy MC method. In conclusion, modeling the thermalization process as a kernel was effective for reducing the computation time.
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DOI：
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发表时间：
2022
期刊：
影响因子：
--
作者：
Toshima Takeo;Fujimori Nao;Yoshizumi Tomoharu;Itoh Shinji;Nagao Yoshihiro;Harada Noboru;Oono Takamasa;Mori Masaki;井川和代
通讯作者：
井川和代
影响因子：
1.6
作者：
Koivunoro, H.;Hippelainen, E.;Joensuu, H.
通讯作者：
Joensuu, H.
使用去除扩散理论进行 BNCT 治疗计划的研究：确定适当去除扩散参数的方法。
影响因子：
3.8
作者：
B. J. Albertson;T. Blue;J. Niemkiewicz
通讯作者：
J. Niemkiewicz
可能用于中子捕获治疗的“超热”中子束的开发和剂量测定 I.“超热”中子束开发
影响因子：
3.5
作者：
R. Fairchild
通讯作者：
R. Fairchild
调试用于临床 BNCT 的治疗计划系统并根据独立的蒙特卡罗剂量计算系统进行验证
DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
Naonori Hu;Hiroki Tanaka;Ryo Kakino;Syuushi Yoshikawa;Mamoru Miyao;Kazuhiko Akita;Kayako Isohashi;Teruhito Aihara;Keiji Nihei;Koji Ono
通讯作者：
Koji Ono