Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly.
Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly.
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DOI：
10.1039/d2mh01117d
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发表时间：
2023-01-03
影响因子：
13.3
通讯作者：
中科院分区：
文献类型：
--
作者：
随着耐药感染的日益普遍，迫切需要开发新型抗菌材料。此外，获得对赋予目标微生物活性的结构特征的完整理解对于实现材料优化至关重要。在这里，我们报道了一种合理的设计来制造具有可变形状，大小和阳离子基团密度的抗菌超分子纳米颗粒，通过利用形状决定模板两亲体和阳离子两亲体之间的非共价相互作用来在纳米颗粒表面引入电荷。我们已经证明，单独的单体阳离子两亲体抗菌活性较差，而互补单元共同组装形成的纳米结构抗菌效率显著提高。此外，一些结构参数的系统变化，如形状、阳离子基团之间的间距和这些纳米结构的大小，使我们能够得出每个参数对整体抗菌性能的作用。最后，我们通过比较它们与细菌膜模拟物结合相互作用的热力学参数，研究了这些具有不同形状和大小但具有相同分子组成的纳米颗粒不同抗菌活性的起源。模板组装法制备不同纳米结构的超分子阳离子纳米材料。纳米材料的尺寸、形状和阳离子基密度对抗菌活性有重要影响。
With the increased prevalence of antibiotic-resistant infections, there is an urgent need to develop novel antibacterial materials. In addition, gaining a complete understanding of the structural features that impart activity toward target microorganisms is essential to enable materials optimisation. Here we have reported a rational design to fabricate antibacterial supramolecular nanoparticles with variable shape, size and cationic group density, by exploiting noncovalent interactions between a shape determining template amphiphile and a cationic amphiphile to introduce charge on the nanoparticle surface. We have shown that the monomeric cationic amphiphile alone showed poor antibacterial activity, whereas nanostructures formed by co-assembling the complementary units showed significantly enhanced antibacterial efficiency. Further, the systematic variation of several structural parameters such as shape, spacing between the cationic groups and size of these nanostructures allowed us to elicit the role of each parameter on the overall antibacterial properties. Finally, we investigated the origin of the differing antibacterial activity of these nanoparticles having different shape and size but with the same molecular composition, by comparing the thermodynamic parameters of their binding interactions with a bacterial membrane mimic. Supramolecular cationic nanomaterials of diverse nanostructure prepared by templated assembly. Size, shape and cationic group density of the nanomaterials play an important role in antibacterial activity.
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影响因子：
4.3
作者：
Lienkamp, Karen;Kumar, Kushi-Nidhi;Tew, Gregory N.
通讯作者：
Tew, Gregory N.
影响因子：
2.7
作者：
Klein T;Gruschwitz FV;Kuchenbrod MT;Nischang I;Hoeppener S;Brendel JC
通讯作者：
Brendel JC
影响因子：
4.6
作者：
Ganewatta, Mitra S.;Tang, Chuanbing
通讯作者：
Tang, Chuanbing
尺寸和形状影响季铵化纳米颗粒的抗菌活性
影响因子：
--
作者：
Inam, Maria;Foster, Jeffrey C.;O'Reilly, Rachel K.
通讯作者：
O'Reilly, Rachel K.
影响因子：
6.4
作者：
Goetz, Katelyn P.;Vermeulen, Derek;Jurchescu, Oana D.
通讯作者：
Jurchescu, Oana D.