Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus.
Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus.
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DOI：
10.1038/srep00781
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发表时间：
2012
影响因子：
4.6
通讯作者：
Liu, Nannan
中科院分区：
文献类型：
--
作者：
Li, Ting;Zhang, Lee;Reid, William R.;Xu, Qiang;Dong, Ke;Liu, Nannan
先前的一项研究在致倦库蚊的整个蚊子钠通道中发现了3个非同义突变和6个同义突变，其发生率与抗药性水平密切相关，并在杀虫剂选择后显著增加。然而，目前尚不清楚这是这一特定抗药性种群所特有的，还是野外蚊子种群对杀虫剂压力做出反应的常见机制。因此，本研究进一步描述了这些突变及其组合在其他领域和氯菊酯选择的蚊子中的特征，发现所有9个突变的共存确实与蚊子对氯氰菊酯的高水平抗性有关。突变组合的比较揭示了几种常见的突变组合，这些突变组合存在于不同田间和氯氰菊酯选择的种群中，以响应高度的抗药性，表明多个突变的共存是不同Cx对杀虫剂抗性的响应中的一种常见事件。Ququiefasciatus蚊子种群。
A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to this specific resistant population or is a common mechanism in field mosquito populations in response to insecticide pressure. The current study therefore further characterized these mutations and their combinations in other field and permethrin selected Culex mosquitoes, finding that the co-existence of all 9 mutations was indeed correlated with the high levels of permethrin resistance in mosquitoes. Comparison of mutation combinations revealed several common mutation combinations presented across different field and permethrin selected populations in response to high levels of insecticide resistance, demonstrating that the co-existence of multiple mutations is a common event in response to insecticide resistance across different Cx. quinquefasciatus mosquito populations.
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