Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson's Disease Impulsivity.
Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson's Disease Impulsivity.
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DOI：
10.1016/j.biopsych.2021.03.002
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发表时间：
2022-02-15
影响因子：
10.6
通讯作者：
Gunduz A
中科院分区：
文献类型：
--
作者：
Eisinger RS;Cagle JN;Alcantara JD;Opri E;Cernera S;Le A;Torres Ponce EM;Lanese J;Nelson B;Lopes J;Hundley C;Ravy T;Wu SS;Foote KD;Okun MS;Gunduz A
冲动和冲动控制障碍（ICD）在帕金森病（PD）中很常见，并导致发病率增加和生活质量下降。冲动被认为是由异常的奖励处理和抑制控制引起的，但目前还不清楚为什么丘脑底核（subthalamic nucleus，DBS）或苍白球（globus pallidus internus，GPi）的脑深部刺激（deep brain stimulation，DBS）会影响冲动的水平。我们的目的是使用DBS电极的侵入性局部场电位（LFP）记录来评估EEG和GPi在冲动性中的作用。我们在39名女性和男性PD患者中测量了简单奖励Go/No-Go范式期间的LFP，这些患者表现出不同量的冲动，这些患者正在接受单侧DBS的DBS（18个核）或GPi（28个核）。我们确定了奖励特异性LFP事件相关电位，并将其与冲动严重程度相关联。在这两个结构的LFPs调制奖励特定的去和不去刺激评价，奖励反馈，和损失反馈。运动和边缘功能在GPi中是解剖学上可分离的，但在GPi中不是。在参与者中，LFP奖励处理反应在大脑皮层和GPi中唯一依赖于冲动的严重程度。本研究建立了LFP相关的冲动在大脑皮层和GPi区域内，我们提出了一个模型，基底神经节奖励处理，其中包括自下而上的作用的GPi奖励显着性和自上而下的作用的大脑皮层在认知控制。
Impulsivity and impulse control disorders (ICDs) are common in Parkinson’s disease (PD) and lead to increased morbidity and reduced quality of life. Impulsivity is thought to arise from aberrant reward processing and inhibitory control, but it is unclear why deep brain stimulation (DBS) of either the subthalamic nucleus (STN) or globus pallidus internus (GPi) impacts levels of impulsivity. Our aim was to assess the role of the STN and GPi in impulsivity using invasive local field potential (LFP) recordings from DBS electrodes. We measured LFPs during a simple rewarding Go/No-Go paradigm in 39 female and male human PD patients manifesting variable amounts of impulsivity that were undergoing unilateral DBS of either the STN (18 nuclei) or GPi (28 nuclei). We identified reward-specific LFP event-related potentials and correlated them to impulsivity severity. LFPs in both structures modulated during reward-specific Go and No-Go stimulus evaluation, reward feedback, and loss feedback. Motor and limbic functions were anatomically separable in the GPi but not the STN. Across participants, LFP reward processing responses in the STN and GPi uniquely depended on the severity of impulsivity. This study establishes LFP correlates of impulsivity within the STN and GPi regions and we propose a model for basal ganglia reward processing which includes the bottom-up role of the GPi in reward salience and the top-down role of the STN in cognitive control.
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影响因子：
5.3
作者：
Baker, Phillip M.;Jhou, Thomas;Vicentic, Aleksandra
通讯作者：
Vicentic, Aleksandra
影响因子：
4.6
作者：
Eisinger, Robert S.;Scott, Bonnie M.;Gunduz, Aysegul
通讯作者：
Gunduz, Aysegul
影响因子：
5.7
作者：
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通讯作者：
Bastin, Julien
影响因子：
3.4
作者：
Espinosa-Parrilla, Juan-Francisco;Baunez, Christelle;Apicella, Paul
通讯作者：
Apicella, Paul
影响因子：
5.7
作者：
Fiore VG;Nolte T;Rigoli F;Smittenaar P;Gu X;Dolan RJ
通讯作者：
Dolan RJ