Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study.
Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study.
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DOI：
10.1371/journal.pone.0164648
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Tsugane S
中科院分区：
文献类型：
--
作者：
Budhathoki S;Yamaji T;Iwasaki M;Sawada N;Shimazu T;Sasazuki S;Yoshida T;Tsugane S
流行病学和实验证据表明，维生素D可以预防结直肠癌的风险。编码维生素D受体（VDR）的基因多态性介导了维生素D的大多数已知细胞效应，已被认为改变了这种关联。在这里，使用标签SNP方法，我们全面评估了常见遗传变异在VDR中的作用及其与日本人群结直肠癌风险相关的血浆维生素D水平的相互作用。从日本公共卫生中心前瞻性队列研究的参与者中选择了356例结直肠癌病例和709例匹配的对照受试者。在这些受试者中，选择29个VDR单核苷酸多态性（SNP）进行基因分型，并测量血浆维生素D浓度。条件Logistic回归模型用于估计结直肠癌的比值比（OR）和95%置信区间（CI），并对潜在的混杂因素进行调整。其中，8个VDR SNPs（rs2254210、rs1540339、rs2107301、rs11168267、rs11574113、rs731236、rs3847987和rs11574143）与结直肠癌的发病风险名义上相关，后5个SNPs位于3 ′区（P = 0.01-0.048）。此外，在上述5个3 ′区SNPs中，3个SNPs（rs11574113、rs3847987和rs11574143）的负相关似乎仅在血浆维生素D浓度高的人群中明显。然而，这些直接的和暗示性的相互作用分析关联都不显着后，多次检验调整。总体而言，本研究的结果仅为日本人群中VDR常见遗传变异与结直肠癌风险之间的关联提供了有限的支持。
Epidemiological and experimental evidence suggest that vitamin D is protective against the risk of colorectal cancer. Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic variants in VDR and their interaction with plasma vitamin D levels in relation to colorectal cancer risk in Japanese populations. A total of 356 colorectal cancer cases and 709 matched control subjects were selected from the participants of the Japan Public Health Center-based Prospective Cohort Study. Among these subjects, 29 VDR single nucleotide polymorphisms (SNPs) were selected and genotyped, and plasma vitamin D concentrations were measured. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of colorectal cancer, with adjustment for potential confounding factors. Among the results, eight VDR SNPs, namely rs2254210, rs1540339, rs2107301, rs11168267, rs11574113, rs731236, rs3847987 and rs11574143, the latter 5 of which were located in the 3′ region, were nominally associated with the risk of colorectal cancer (P = 0.01–0.048). Furthermore, of the above 5 3′ region SNPs, the inverse associations for 3 SNPs (rs11574113, rs3847987 and rs11574143) appeared to be evident only in those with high plasma vitamin D concentration. However, neither of these direct and suggestive interaction analysis associations was significant after multiple testing adjustment. Overall, the findings of this study provide only limited support for an association between common genetic variations in VDR and colorectal cancer risk in the Japanese population.
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影响因子：
3.3
作者：
Hibler, Elizabeth A.;Jacobs, Elizabeth T.;Jurutka, Peter W.
通讯作者：
Jurutka, Peter W.
影响因子：
7.1
作者：
Ishihara, Junko;Inoue, Manami;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
影响因子：
8.8
作者：
Otani, T.;Iwasaki, M.;Sasazuki, S.;Inoue, M.;Tsugane, S.
通讯作者：
Tsugane, S.
DOI：
10.1158/1055-9965.epi-11-0916
发表时间：
2012-02
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hibler EA;Hu C;Jurutka PW;Martinez ME;Jacobs ET
通讯作者：
Jacobs ET
影响因子：
5
作者：
Jorde, Rolf;Sneve, Monica;Grimnes, Guri
通讯作者：
Grimnes, Guri