Probability that there is a mammalian counterpart of cardiac clock in insects.

Probability that there is a mammalian counterpart of cardiac clock in insects.
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DOI:
10.1002/arch.21867
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发表时间:
2022-05
影响因子:
2.2
通讯作者:
--
中科院分区:
农林科学4区
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--
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无论超极化激活的环核苷酸门控非选择性阳离子通道(HCN或有趣电流If)是否参与起搏-反复心跳,它都归因于所有可兴奋细胞(包括无脊椎动物)的电活动。在后一组动物中,根据变时性和变力性阐明了心脏的电信号和功能。虽然在包括昆虫在内的简单模型中,实验结果是可重复的和稳健的,但“心脏时钟”机制在起搏中的参与并不确定。在这项试验中,心跳的机制是通过集中比较昆虫和哺乳动物的心脏。
Whether or not the hyperpolarization-activated cyclic nucleotide-gated nonselective cation channel (HCN or funny current If) is involved in pacemaking – recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono- and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.
DOI: 10.1113/jphysiol.1990.sp018219
发表时间: 1990-09-01
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