Quantitative MRI evaluation of glaucomatous changes in the visual pathway.
Quantitative MRI evaluation of glaucomatous changes in the visual pathway.
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DOI：
10.1371/journal.pone.0197027
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Nakazawa T
中科院分区：
文献类型：
--
作者：
Fukuda M;Omodaka K;Tatewaki Y;Himori N;Matsudaira I;Nishiguchi KM;Murata T;Taki Y;Nakazawa T
本研究的目的是研究青光眼的形态学变化，定量与基于体素的形态测量（VBM），一个标准化的MRI技术，并澄清青光眼损害和区域性变化之间的关系，在开角型青光眼（OAG）患者的大脑视觉皮层。31例OAG患者（年龄：55.9 ± 10.7，男：女= 9：22）和20例年龄匹配的对照组（年龄：54.9 ± 9.8，男：女= 10：10）被纳入本研究。采用T2加权MRI手动测量视神经的横截面积（CSA）。视觉皮层的图像是用T1加权的3D磁化准备的梯度回波（MPWS）测序快速采集来获取的，并且标准化的区域视觉皮层体积，即，用基于统计参数映射8（SPM 8）分析的标准化技术计算Brodmann区（BA）17、18和19中的灰质密度（GMD）。我们比较了对照组和OAG患者视觉皮层的区域GMD。斯皮尔曼等级相关分析用于确定BA 17、18和19中视神经CSA和GMD之间的关系。我们发现，正常人和OAG患者在视神经CSA（p < 0.001）和视皮层GMD（BA 17（p = 0.030）、BA 18（p = 0.003）和BA 19（p = 0.005））方面存在显著差异。此外，我们发现视神经CSA和视皮层GMD之间在BA 19中有显著相关性（r = 0.33，p = 0.023），但在BA 17（r = 0.17，p = 0.237）或BA 18（r = 0.24，p = 0.099）中没有相关性。GMD的定量MRI参数评估可以检测BA 17、18和19中视皮层的脑胶质瘤相关解剖萎缩。此外，在OAG患者中，BA 19中的GMD与视神经以及视网膜的损伤程度显著相关。这是第一次证明负责高阶视觉功能的大脑皮层与青光眼严重程度之间的关联。因此，用MRI评价视皮层是一种非常有前途的客观检查OAG的潜在方法。
The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG). Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female = 10: 10) were included in this study. The cross-sectional area (CSA) of the optic nerve was manually measured with T2-weighed MRI. Images of the visual cortex were acquired with T1-weighed 3D magnetization-prepared rapid acquisition with gradient echo (MPRAGE) sequencing, and the normalized regional visual cortex volume, i.e., gray matter density (GMD), in Brodmann areas (BA) 17, 18, and 19, was calculated with a normalizing technique based on statistic parametric mapping 8 (SPM8) analysis. We compared the regional GMD of the visual cortex in the control subjects and OAG patients. Spearman’s rank correlation analysis was used to determine the relationship between optic nerve CSA and GMD in BA 17, 18, and 19. We found that the normal and OAG patients differed significantly in optic nerve CSA (p < 0.001) and visual cortex GMD in BA 17 (p = 0.030), BA 18 (p = 0.003), and BA 19 (p = 0.005). In addition, we found a significant correlation between optic nerve CSA and visual cortex GMD in BA 19 (r = 0.33, p = 0.023), but not in BA 17 (r = 0.17, p = 0.237) or BA 18 (r = 0.24, p = 0.099). Quantitative MRI parametric evaluation of GMD can detect glaucoma-associated anatomical atrophy of the visual cortex in BA 17, 18, and 19. Furthermore, GMD in BA 19 was significantly correlated to the damage level of the optic nerve, as well as the retina, in patients with OAG. This is the first demonstration of an association between the cortex of the brain responsible for higher-order visual function and glaucoma severity. Evaluation of the visual cortex with MRI is thus a very promising potential method for objective examination in OAG.
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DOI：
10.1136/bjo.2008.138172
发表时间：
2009-01
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Gupta N;Greenberg G;de Tilly LN;Gray B;Polemidiotis M;Yücel YH
通讯作者：
Yücel YH
原发性开角型青光眼患者的大脑结构异常：一项 3T MR 成像研究
影响因子：
4.4
作者：
Chen, Wei W.;Wang, Ningli;Gong, Qiyong
通讯作者：
Gong, Qiyong
影响因子：
13.7
作者：
Leske, M. Cristina;Heijl, Anders;Yang, Zhongming
通讯作者：
Yang, Zhongming
影响因子：
5.3
作者：
Nakazawa, Toru;Nakazawa, Chifuyu;Benowitz, Larry I.
通讯作者：
Benowitz, Larry I.
影响因子：
13.7
作者：
Iwase, A;Suzuki, Y;Kitazawa, Y
通讯作者：
Kitazawa, Y