Whole-body vibration decreases the proliferativeb response of TCD4(+) cells in elderly individuals with knee osteoarthritis.
Whole-body vibration decreases the proliferativeb response of TCD4(+) cells in elderly individuals with knee osteoarthritis.
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DOI：
10.1590/s0100-879x2012007500139
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Lacerda AC
中科院分区：
文献类型：
--
作者：
Tossige-Gomes R;Avelar NC;Simão AP;Neves CD;Brito-Melo GE;Coimbra CC;Rocha-Vieira E;Lacerda AC
目的：探讨下蹲训练加全身振动(频率35~40 Hz，振幅4 mm)对老年膝骨性关节炎患者T细胞增殖反应的影响。这项研究是一项随机对照试验，其中选定的变量在训练前和训练后12周进行评估。26名受试者(72±5岁)随机分为3组：1)有WBV的下蹲训练(N=8)，2)无WBV的下蹲训练(N=10)，3)对照组(N=8)。60岁的≥女性，并且被诊断出至少有一个膝盖的骨性关节炎是符合条件的。干预包括连续12周的下蹲运动训练，每周3次。训练前后采集外周血，获取外周血单个核细胞。用流式细胞仪检测干预前后的羧基荧光素琥珀酰亚胺酯荧光衰减率(Δ)来评价TCD_4~+和T_CD8~+细胞的增殖情况。WBV组TCD4+细胞增殖反应(P=0.02，效应量=1.0)较对照组显著降低(23%)，而TCD8+细胞增殖反应率组间差异无统计学意义(P=0.12，效应量=2.23)。这些数据表明，在蹲下运动训练中增加WBV可能会调节T细胞介导的免疫，最大限度地减少或减缓老年膝骨性关节炎患者的疾病进展。
The aim of this study was to investigate the effect of adding whole-body vibration (WBV; frequency = 35 to 40 Hz; amplitude = 4 mm) to squat training on the T-cell proliferative response of elderly patients with osteoarthritis (OA) of the knee. This study was a randomized controlled trial in which the selected variables were assessed before and after 12 weeks of training. Twenty-six subjects (72 ± 5 years of age) were divided into three groups: 1) squat training with WBV (WBV, N = 8); 2) squat training without WBV (N = 10), and 3) a control group (N = 8). Women who were ≥60 years of age and had been diagnosed with OA in at least one knee were eligible. The intervention consisted of 12 uninterrupted weeks of squatting exercise training performed 3 times/week. Peripheral blood mononuclear cells were obtained from peripheral blood collected before and after training. The proliferation of TCD4+ and TCD8+ cells was evaluated by flow cytometry measuring the carboxyfluorescein succinimidyl ester fluorescence decay before and after the intervention (Δ). The proliferative response of TCD4+ cells (P = 0.02, effect size = 1.0) showed a significant decrease (23%) in the WBV group compared to the control group, while there was no difference between groups regarding the proliferative response of TCD8+ cells (P = 0.12, effect size = 2.23). The data suggest that the addition of WBV to squat exercise training might modulate T-cell-mediated immunity, minimizing or slowing disease progression in elderly patients with OA of the knee.
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DOI：
10.1084/jem.182.5.1357
发表时间：
1995-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Openshaw P;Murphy EE;Hosken NA;Maino V;Davis K;Murphy K;O'Garra A
通讯作者：
O'Garra A
影响因子：
7
作者：
Ishii, H;Tanaka, H;Yoshino, S
通讯作者：
Yoshino, S
DOI：
10.1249/01.mss.0000069752.96438.b0
发表时间：
2003-06-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Delecluse, C;Roelants, M;Verschueren, S
通讯作者：
Verschueren, S
影响因子：
2.2
作者：
BICALHO, HMS;GONTIJO, CM;NOGUEIRAMACHADO, JA
通讯作者：
NOGUEIRAMACHADO, JA
影响因子：
2.6
作者：
Pereira Avelar, Nubia Carelli;Simao, Adriano Prado;Rodrigues Lacerda, Ana Cristina
通讯作者：
Rodrigues Lacerda, Ana Cristina