Probiotic design

Probiotic design
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益生菌设计

DOI:
10.1080/13602365.2021.1880822
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发表时间:
2021
期刊:
The Journal of Architecture
影响因子:
--
通讯作者:
Beckett R
Beckett R
中科院分区:
--
文献类型:
--
作者:
Beckett R

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为了响应医学领域的进步,现在了解细菌对人类健康的整体作用,这项研究提出了一种新的益生菌方法,用于设计与有益微生物有关的健康建筑。这项研究从根本上挑战了健康建筑的现代方法,这些方法将更少的微生物视为默认的健康状况。益生菌设计建立在当代对微生物组的理解以及将环境微生物多样性重新引入建筑物的需要之上。该研究采用微生物学和建筑学之间的跨学科方法,旨在开发嵌入有益细菌的生物材料,用于建筑物,直接塑造室内微生物组,使其达到更健康的微生物条件。这种方法利用体外和计算机方法的混合来探索活益生菌材料的设计,制造和存活。然后将这些按比例放大到建筑物大小,作为一系列益生菌瓷砖表面,这些表面又安装在测试空间中,以监测它们对室内微生物组的影响。该研究提供了将活细菌整合到陶瓷和混凝土材料中的成功方法的证据。由于这些被证明可以抑制病原体的生长,它们还可以直接增加环境微生物的存在,使其成为健康的室内微生物组。
Responding to advances in medical fields that now understand the integral role that bacteria play towards human health, this research proposes a novel probiotic approach towards designing healthy buildings in relation to beneficial microbes. This research fundamentally challenges modern approaches to healthy buildings that assume fewer microbes as the default healthy condition. Probiotic design builds on the contemporary understanding of the microbiome and the need for reintroducing environmental microbial diversity into buildings. The research uses an interdisciplinary approach between microbiology and architecture which aims to develop living materials embedded with beneficial bacteria for buildings to directly shape the indoor microbiome towards a healthier microbial condition. This approach utilises a mix of in vitro and in silico methodologies to explore the design, fabrication, and survival of living probiotic materials. These are then scaled up to building size as a series of probiotic tile surfaces which are in turn installed in a test space to monitor their effect on the indoor microbiome. The research provides evidence of a successful methodology for integrating viable bacteria into ceramic and concrete materials. As these are proved to inhibit the growth of pathogens, they can also directly increase environmental microbial presence towards healthy indoor microbiomes.
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