Skin graft survival in the uterine lumen of ewes treated with progesterone.
Skin graft survival in the uterine lumen of ewes treated with progesterone.
复制标题
用黄体酮治疗的母羊子宫腔内的皮肤移植存活。
DOI：
10.1111/j.1600-0897.1986.tb00062.x
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
SegersonJr,EC
中科院分区：
文献类型：
--
作者：
Hansen,PJ;Bazer,FW;SegersonJr,EC
进行了一项实验，以确定黄体酮对放置在卵巢切除母羊子宫腔内的皮肤移植物存活的影响。动物用玉米油媒介物（n = 4）或孕酮以50（n = 3）或200 mg/天（n = 3）处理30天。然后将自体移植物和同种异体移植物放置在每个子宫中，并在检查移植物的存活率之前继续治疗额外的30天。所有自体移植物在移植后30天均存在，并且在组织学检查时大多数看起来健康。移植后30天，将同种异体移植物置于孕酮处理母羊的子宫腔内，但组织学外观坏死。放置在玉米油处理母羊子宫内的同种异体移植物被完全吸收。检查子宫腔中积聚的子宫分泌物对植物血凝素（PHA）刺激的淋巴细胞的[3 H-甲基]胸苷掺入的抑制作用。孕酮处理的母羊子宫腔中的免疫抑制活性总量大于（P< 0.05）玉米油处理的母羊。孕酮处理母羊子宫分泌物中孕酮的浓度范围为0.3 - 3.4 ng/ml。PHA刺激的淋巴细胞中的胸苷掺入不受高达500 ng/ml孕酮体外处理的影响。总之，孕酮延迟了放置在子宫腔的皮肤移植物的再吸收。结果与孕酮通过刺激免疫抑制物质分泌到子宫腔来介导这种效应的假设一致。
An experiment was conducted to determine the effect of progesterone on survival of skin transplants placed in the uterine lumen of ovariectomized ewes. Animals were treated for 30 days with either a corn oil vehicle (n = 4) or progesterone at 50 (n = 3) or 200 mg/day (n = 3). An autograft and allograft were then placed in each uterus, and treatments were continued for an additional 30 days before grafts were examined for survival. All autografts were present 30 days after grafting and most appeared healthy upon histological examination. Allografts placed into the uterine lumen of progesterone‐treated ewes were present 30 days after grafting but were necrotic in histological appearance. Allografts placed within the uterus of corn oil‐treated ewes were completely resorbed. Uterine secretions that accumulated in the uterine lumen were examined for inhibitory effects on [3H‐methyl]thymidine incorporation by lymphocytes stimulated with phytohemagglutinin (PHA). The total amount of immunosuppressive activity in the uterine lumen was greater (P< 0.05) for progesterone‐treated ewes than for corn oil‐treated ewes. Concentrations of progesterone in uterine secretions of progesterone‐treated ewes ranged from 0.3 to 3.4 ng/ml. Thymidine incorporation into PHA‐stimulated lymphocytes was not affected by in vitro treatment with up to 500 ng/ml of progesterone. In conclusion, progesterone delayed resorption of skin allografts placed in the uterine lumen. Results are consistent with the hypothesis that progesterone mediated this effect by stimulating the secretion of immunosuppressive substances into the uterine lumen.
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影响因子：
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作者：
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DOI：
10.1016/b978-0-408-10865-2.50014-1
发表时间：
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期刊：
Journal of steroid biochemistry
影响因子：
--
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影响因子：
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作者：
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