Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children.
Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children.
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儿童急性简单临床疟疾感染后，周围B细胞亚群的改变。
DOI：
10.1186/1475-2875-7-238
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发表时间：
2008-11-18
期刊：
影响因子：
3
通讯作者：
Rochford R
中科院分区：
文献类型：
--
作者：
Asito AS;Moormann AM;Kiprotich C;Ng'ang'a ZW;Ploutz-Snyder R;Rochford R
恶性疟原虫对B细胞稳态的影响尚未得到很好的表征。本研究调查了幼儿急性疟疾发作是否导致外周B细胞表型的变化。使用流式细胞荧光分析，B细胞表型在外周血中发现的2-5岁的儿童的特点是在急性无并发症的临床疟疾发作和4周后恢复和健康的年龄匹配的控制。急性期CD 19 + B淋巴细胞显著减少。基于IgD和CD 38表达的外周血中CD 19 + B细胞亚群的表征揭示了在急性疟疾期间初始1 CD 38-IgD+ B细胞的数量显著减少，而CD 38 +IgD-记忆3 B细胞的数量增加。对外周B细胞表型的进一步分析还发现，在急性疟疾发作后，儿童中过渡性CD 10 + CD 19 + B细胞扩增，高达25%的总CD 19 + B细胞库存在于该亚群中。经历急性无并发症临床疟疾发作的儿童经历了B细胞稳态的严重紊乱。
The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2–5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset. Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.
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DOI：
10.1073/pnas.0511094103
发表时间：
2006-02-14
影响因子：
11.1
作者：
Malaspina, A;Moir, S;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
4.4
作者：
Bohnhorst, JO;Bjorgan, MB;Thompson, KM
通讯作者：
Thompson, KM
DOI：
10.4269/ajtmh.1994.51.372
发表时间：
1994-09-01
影响因子：
3.3
作者：
ELHASSAN, IM;HVIID, L;THEANDER, TG
通讯作者：
THEANDER, TG
影响因子：
4.6
作者：
Worku, S;Bjorkman, A;Christensson, B
通讯作者：
Christensson, B
CBA小鼠中质质体的生发中心结构障碍。
影响因子：
3
作者：
Carvalho, Leonardo J. M.;Ferreira-da-Cruz, Maria F.;Daniel-Ribeiro, Claudio T.;Pelajo-Machado, Marcelo;Lenzi, Henrique L.
通讯作者：
Lenzi, Henrique L.