The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.
The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.
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DOI：
10.1016/j.schres.2014.03.031
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发表时间：
2014-06
影响因子：
4.5
通讯作者：
Hooker CI
中科院分区：
文献类型：
--
作者：
Dodell-Feder D;Delisi LE;Hooker CI
精神分裂症患者的未受影响的一级亲属（即，家族性高风险[FHR]），表现出社会功能障碍的性质相似，但不如其受影响的亲属严重。这些社交困难可能是遗传性破坏默认模式网络（DMN）的结果，例如dMPFC子系统，它与社交认知过程中招募的大脑区域网络重叠。在本研究中，我们调查这种可能性，测试DMN的连接和它的关系，在FHR使用静息状态功能磁共振成像的社会功能。20个胎心率个体和17个对照组在静息状态下接受了功能磁共振成像扫描。假设驱动的功能连接性分析研究了DMN的枢纽，dMPFC子系统和MTL子系统的区域之间的ROI到ROI的相关性。连通性的价值观进行了检查的关系，社会功能和同理心/观点采择的措施。结果表明，FHR表现出减少的连接，特别是在DMN的dMPFC子系统。某些ROI与ROI的相关性预测了所有参与者的社会功能和同理心/观点采择方面。总之，这些数据表明，DMN的dMPFC子系统的破坏可能与精神分裂症的家族风险有关，并且这些内在联系可能对社会功能产生可测量的后果。
Unaffected first-degree relatives of individuals with schizophrenia (i.e., those at familial high-risk [FHR]), demonstrate social dysfunction qualitatively similar though less severe than that of their affected relatives. These social difficulties may be the consequence of genetically conferred disruption to aspects of the default mode network (DMN), such as the dMPFC subsystem, which overlaps with the network of brain regions recruited during social cognitive processes. In the present study, we investigate this possibility, testing DMN connectivity and its relationship to social functioning in FHR using resting-state fMRI. Twenty FHR individuals and 17 controls underwent fMRI during a resting-state scan. Hypothesis-driven functional connectivity analyses examined ROI-to-ROI correlations between the DMN’s hubs, and regions of the dMPFC subsystem and MTL subsystem. Connectivity values were examined in relationship to a measure of social functioning and empathy/perspective-taking. Results demonstrate that FHR exhibit reduced connectivity specifically within the dMPFC subsystem of the DMN. Certain ROI-to-ROI correlations predicted aspects of social functioning and empathy/perspective-taking across all participants. Together, the data indicate that disruption to the dMPFC subsystem of the DMN may be associated with familial risk for schizophrenia, and that these intrinsic connections may carry measurable consequences for social functioning.
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DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
6.6
作者：
Couture, Shannon M.;Penn, David L.;Roberts, David L.
通讯作者：
Roberts, David L.
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
4.5
作者：
Alonso-Solis, Anna;Corripio, Iluminada;de Castro-Manglano, Pilar;Duran-Sindreu, Santiago;Garcia-Garcia, Manuel;Proal, Erika;Nunez-Marin, Fidel;Soutullo, Cesar;Alvarez, Enric;Gomez-Anson, Beatriz;Kelly, Clare;Castellanos, F. Xavier
通讯作者：
Castellanos, F. Xavier