A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma.
A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma.
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近红外荧光成像在肝细胞癌肝切除术中的叙述性回顾
DOI：
10.21037/atm-20-5341
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发表时间：
2021-01
影响因子：
--
通讯作者：
Fang C
中科院分区：
文献类型：
--
作者：
Zhang W;Hu Z;Tian J;Fang C
肝切除术是治疗肝细胞癌（HCC）的主要方法，它要求切除原发性和播散性肿瘤，最大限度地保留正常肝组织。然而，在临床手术中，肉眼和触诊很难识别肿瘤组织及其边界，这往往导致切除不足或过度。近红外荧光（NIRF）成像是一种无创、实时、低成本、高灵敏度的成像技术，在手术导航中得到了广泛的研究。随着荧光成像系统和荧光探针的发展，可以实现术中肿瘤的检测和边缘的界定，使手术更加准确。在NIR区域中HCC的荧光成像的进展集中在传统的第一NIR窗口（NIR-I，700-900 nm），并且最近已经扩展到第二NIR窗口（NIR-II，1，000 - 1，700 nm）。与NIR-I成像相比，NIR-II中的荧光成像具有很大的优势，包括更高的空间分辨率，更深的穿透深度，以及更低的光学吸收和生物基质的散射，最小的组织自发荧光。因此，开发新型的近红外荧光探针用于肝癌的活体成像无疑具有重要的意义，并将直接影响肝脏外科领域的发展。本文综述了近红外荧光成像探针在肝癌切除术中的应用进展，并对近红外荧光成像探针面临的挑战和潜在的机遇进行了讨论。
Hepatectomy is a main therapeutic strategy for hepatocellular carcinoma (HCC), which requires removal of primary and disseminated tumors and maximum preservation of normal liver tissue. However, in a clinical operation, it is difficult to recognize the tumor tissue and its boundary with the naked eye and palpation, which often leads to insufficient or excessive resection. Near-infrared fluorescence (NIRF) imaging, a non-invasive, real-time, low-cost, and highly sensitive imaging technique has been extensively studied in surgical navigation. With the development of fluorescence imaging system and fluorescent probe, intraoperative tumor detection and margin definition can be achieved, making the operation more accurate. Advances in fluorescence imaging of HCC in the NIR region have focused on the traditional first NIR window (NIR-I, 700–900 nm), and have recently been extended to the second NIR window (NIR-II, 1,000–1,700 nm). Compared with NIR-I imaging, fluorescence imaging in the NIR-II exhibits great advantages, including higher spatial resolution, deeper penetration depth, and lower optical absorption and scattering from biological substrates with minimal tissue autofluorescence. There is no doubt that developing novel NIRF probes for in vivo imaging of HCC has high significance and direct impact on the field of liver surgery. In this article, the development of various NIRF probes for fluorescence image guided HCC hepatectomy is reviewed, and current challenges and potential opportunities of these imaging probes are discussed.
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影响因子：
9
作者：
Aufhauser DD Jr;Sadot E;Murken DR;Eddinger K;Hoteit M;Abt PL;Goldberg DS;DeMatteo RP;Levine MH
通讯作者：
Levine MH
影响因子：
2.5
作者：
Gotoh, Kunihito;Yamada, Terumasa;Imaoka, Shingi
通讯作者：
Imaoka, Shingi
影响因子：
--
作者：
Chen Q;Shang W;Zeng C;Wang K;Liang X;Chi C;Liang X;Yang J;Fang C;Tian J
通讯作者：
Tian J
影响因子：
16.6
作者：
Antaris AL;Chen H;Diao S;Ma Z;Zhang Z;Zhu S;Wang J;Lozano AX;Fan Q;Chew L;Zhu M;Cheng K;Hong X;Dai H;Cheng Z
通讯作者：
Cheng Z
影响因子：
12.4
作者：
Hernandez R;Sun H;England CG;Valdovinos HF;Ehlerding EB;Barnhart TE;Yang Y;Cai W
通讯作者：
Cai W