Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group.
Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group.
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1053名重度抑郁症患者失眠严重程度与脑结构的相关性：ENIGMA抑郁症工作组的研究结果
DOI：
10.1038/s41398-020-01109-5
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发表时间：
2020-12-08
影响因子：
6.8
通讯作者：
Van Someren EJW
中科院分区：
文献类型：
--
作者：
Leerssen J;Blanken TF;Pozzi E;Jahanshad N;Aftanas L;Andreassen OA;Baune BT;Brack I;Carballedo A;Ching CRK;Dannlowski U;Dohm K;Enneking V;Filimonova E;Fingas SM;Frodl T;Godlewska BR;Goltermann J;Gotlib IH;Grotegerd D;Gruber O;Harris MA;Hatton SN;Hawkins E;Hickie IB;Jaworska N;Kircher T;Krug A;Lagopoulos J;Lemke H;Li M;MacMaster FP;McIntosh AM;McLellan Q;Meinert S;Mwangi B;Nenadić I;Osipov E;Portella MJ;Redlich R;Repple J;Sacchet MD;Sämann PG;Simulionyte E;Soares JC;Walter M;Watanabe N;Whalley HC;Yüksel D;Veltman DJ;Thompson PM;Schmaal L;Van Someren EJW
It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD.
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影响因子：
4.8
作者：
Dotson VM;Szymkowicz SM;Sozda CN;Kirton JW;Green ML;O'Shea A;McLaren ME;Anton SD;Manini TM;Woods AJ
通讯作者：
Woods AJ
影响因子：
5.6
作者：
Kocevska, Desana;Muetzel, Ryan L.;Tiemeier, Henning
通讯作者：
Tiemeier, Henning
影响因子：
25
作者：
Damasio, AR;Grabowski, TJ;Hichwa, RD
通讯作者：
Hichwa, RD
影响因子：
4.4
作者：
Bumb, Jan M.;Schilling, Claudia;Nolte, Ingo
通讯作者：
Nolte, Ingo
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y