Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease.
Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease.
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研究肌肉功能、可塑性和疾病的组织工程骨骼肌模型。
DOI：
10.3389/fphys.2021.619710
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发表时间：
2021
影响因子：
4
通讯作者：
Khodabukus A
中科院分区：
文献类型：
--
作者：
Khodabukus A
骨骼肌具有显着的可塑性，可以对多种信号（例如运动输入、运动和疾病）进行功能适应。小动物模型对于阐明调节骨骼肌适应和可塑性的分子机制至关重要。然而，这些小动物模型无法准确模拟人类肌肉疾病，导致临床治疗效果不佳。在这里，我们回顾了体外三维组织工程骨骼肌模型在研究肌肉功能、可塑性和疾病方面的潜力。首先，我们讨论体外骨骼肌模型的生成和功能。然后，我们讨论体内调节骨骼肌纤维类型的遗传、神经和激素因素，以及当前体外模型研究肌纤维类型调节的能力。我们还评估了这些系统以特定于患者的方式使用的潜力，以准确建模并获得对杜氏肌营养不良症 (DMD) 和体积肌肉损失等疾病的新见解。最后，我们讨论了组织工程骨骼肌模型所需的未来发展，以使其变得更加成熟、仿生并广泛用于研究肌肉生理学、疾病和临床用途。
Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a wide range of signals such as motor input, exercise, and disease. Small animal models have been pivotal in elucidating the molecular mechanisms regulating skeletal muscle adaptation and plasticity. However, these small animal models fail to accurately model human muscle disease resulting in poor clinical success of therapies. Here, we review the potential of in vitro three-dimensional tissue-engineered skeletal muscle models to study muscle function, plasticity, and disease. First, we discuss the generation and function of in vitro skeletal muscle models. We then discuss the genetic, neural, and hormonal factors regulating skeletal muscle fiber-type in vivo and the ability of current in vitro models to study muscle fiber-type regulation. We also evaluate the potential of these systems to be utilized in a patient-specific manner to accurately model and gain novel insights into diseases such as Duchenne muscular dystrophy (DMD) and volumetric muscle loss. We conclude with a discussion on future developments required for tissue-engineered skeletal muscle models to become more mature, biomimetic, and widely utilized for studying muscle physiology, disease, and clinical use.
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影响因子：
5.5
作者：
BARANY, M;CLOSE, RI
通讯作者：
CLOSE, RI
影响因子：
1.8
作者：
Al-Himdani S;Jessop ZM;Al-Sabah A;Combellack E;Ibrahim A;Doak SH;Hart AM;Archer CW;Thornton CA;Whitaker IS
通讯作者：
Whitaker IS
影响因子：
6.1
作者：
Adams AM;VanDusen KW;Kostrominova TY;Mertens JP;Larkin LM
通讯作者：
Larkin LM
血管细胞对成肌干细胞行为的调控 卫星细胞、内皮周围细胞和内皮细胞的 "三人行"
影响因子：
4.3
作者：
Abou-Khalil, Rana;Mounier, Remi;Chazaud, Benedicte
通讯作者：
Chazaud, Benedicte
影响因子：
4.8
作者：
Bian, Weining;Bursac, Nenad
通讯作者：
Bursac, Nenad