P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury.
P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury.
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P300 作为评估脑外伤后神经认知障碍的潜在指标
DOI：
10.3389/fneur.2021.690792
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发表时间：
2021
影响因子：
3.4
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Li H;Li N;Xing Y;Zhang S;Liu C;Cai W;Hong W;Zhang Q
创伤性脑损伤（TBI）后神经认知障碍的客观评价指标很少。P300在精神障碍、认知功能障碍和脑损伤中被广泛研究。日常生活能力和社会功能是评价脑外伤后神经认知障碍的关键指标。本研究的重点是P300与日常生活活动障碍和社会功能障碍的相关性。根据ICD-10，我们招募了234例TBI后神经认知障碍患者和277名年龄和性别匹配的健康志愿者。采用社会残疾筛查量表（SDSS）、日常生活活动量表（ADL）和脑外伤后人格改变量表对患者的日常生活活动和社会功能进行评估。P300是由一个视觉上古怪的范式引起的。结果显示，患者组ADL量表、SDSS量表、人格改变量表得分均显著高于对照组。患者组Fz、Cz、Pz波幅均显著低于对照组，且与ADL、SDSS量表得分呈负相关。综上所述，P300波幅越低，日常生活能力和社交功能的损害越大，表明脑外伤后神经认知障碍的严重程度越高。P300可能是评估脑外伤后神经认知障碍严重程度的一个潜在指标。
Few objective indices can be used when evaluating neurocognitive disorders after a traumatic brain injury (TBI). P300 has been widely studied in mental disorders, cognitive dysfunction, and brain injury. Daily life ability and social function are key indices in the assessment of neurocognitive disorders after a TBI. The present study focused on the correlation between P300 and impairment of daily living activity and social function. We enrolled 234 patients with neurocognitive disorders after a TBI according to ICD-10 and 277 age- and gender-matched healthy volunteers. The daily living activity and social function were assessed by the social disability screening schedule (SDSS) scale, activity of daily living (ADL) scale, and scale of personality change following a TBI. P300 was evoked by a visual oddball paradigm. The results showed that the scores of the ADL scale, SDSS scale, and scale of personality change in the patient group were significantly higher than those in the control group. The amplitudes of Fz, Cz, and Pz in the patient group were significantly lower than those in the control group and were negatively correlated with the scores of the ADL and SDSS scales. In conclusion, a lower P300 amplitude means a greater impairment of daily life ability and social function, which suggested more severity of neurocognitive disorders after a TBI. P300 could be a potential indicator in evaluating the severity of neurocognitive disorders after a TBI.
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影响因子：
5
作者：
Alberti, A;Sarchielli, P;Gallai, V
通讯作者：
Gallai, V
影响因子：
3
作者：
Almeida, Pedro R.;Vieira, Joana B.;Marques-Teixeira, Joao
通讯作者：
Marques-Teixeira, Joao
影响因子：
4.7
作者：
Lai, Chiou-Lian;Lin, Ruey-Tay;Liu, Ching-Kuan
通讯作者：
Liu, Ching-Kuan
影响因子：
--
作者：
DeKosky, Steven T.;Abrahamson, Eric E.;Ikonomovic, Milos D.
通讯作者：
Ikonomovic, Milos D.
DOI：
10.1016/s0168-5597(97)00085-3
发表时间：
1998-04-01
期刊：
EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
García-Larrea, L;Cézanne-Bert, G
通讯作者：
Cézanne-Bert, G