Lateralization Effects on Cerebral Blood Flow in Patients With Unilateral Pulsatile Tinnitus Measured With Arterial Spin Labeling.
Lateralization Effects on Cerebral Blood Flow in Patients With Unilateral Pulsatile Tinnitus Measured With Arterial Spin Labeling.
复制标题
用动脉自旋标记测量单侧搏动性耳鸣患者脑血流的侧化效应
DOI：
10.3389/fnhum.2020.591260
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发表时间：
2020
影响因子：
2.9
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Li X;Zhao P;Qiu X;Ding H;Lv H;Yang Z;Gong S;Wang Z
目的：研究左侧和右侧脉动性耳鸣（LPT和RPT）患者和健康对照者（HC）的脑血流量（CBF）差异，以进一步探讨动脉自旋标记（ASL）PT的偏侧效应。方法：回顾性分析21例RPT、17例LPT和21例HC患者的ASL资料。采用体素分析和感兴趣区分析探讨三组脑血流的差异。耳鸣障碍量表（THI）评分和耳鸣持续时间从每个病人。结果如下：体素分析显示，RPT和LPT患者左侧顶下回的CBF均高于HC患者（P < 0.001）。感兴趣区分析显示，左侧初级听皮层（PAC）的CBF高于右侧，右侧次级听皮层（SAC）和听觉联合皮层的CBF高于左侧。这些偏侧化效应在所有三组中都存在。与HC相比，RPT患者左侧PAC和SAC的CBF增加（PAC：P = 0.036; SAC：P = 0.012）。PT持续时间和THI评分与上述脑区CBF改变无明显相关性。结论：左侧顶下回的CBF增加是RPT和LPT患者的共同特征，无论PT的感知侧如何。听觉皮层的偏侧化效应可能是正常大脑的一个生理特征。这些发现可能为理解PT的神经病理生理学提供新的视角。
Purpose: To investigate cerebral blood flow (CBF) differences in patients with left- and right-sided pulsatile tinnitus (LPT and RPT) and healthy controls (HCs) to further explore the lateralization effects of PT using arterial spin labeling (ASL). Methods: ASL data from 21 RPT patients, 17 LPT patients and 21 HCs were reviewed. Voxel-wise analysis and region of interest analysis were performed to explore differences in CBF among the three groups. Tinnitus Handicap Inventory (THI) score and tinnitus duration were obtained from each patient. Results: Voxel-wise analysis showed that the CBF of the left inferior parietal gyrus was increased in both RPT and LPT patients compared with HCs (P < 0.001). Region of interest analysis revealed that the CBF of the left primary auditory cortex (PAC) was higher than that of the right, while the CBF of the right secondary auditory cortex (SAC) and auditory association cortex was higher than that of the left. These lateralization effects were present in all three groups. Compared with HCs, RPT patients showed increased CBF in the left PAC and SAC (PAC: P = 0.036; SAC: P = 0.012). No significant correlations were found between PT duration or THI score and altered CBF in above regions. Conclusion: Increased CBF in the left inferior parietal gyrus is a common feature in both RPT and LPT patients, regardless of the perceived side of PT. The lateralization effects of auditory cortices may be a physiological characteristic of the normal brain. These findings may provide a new perspective for understanding the neurological pathophysiology of PT.
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影响因子：
6.1
作者：
Dong C;Zhao PF;Yang JG;Liu ZH;Wang ZC
通讯作者：
Wang ZC
影响因子：
3.3
作者：
Geven, L. I.;de Kleine, E.;van Dijk, P.
通讯作者：
van Dijk, P.
影响因子：
2.9
作者：
Cheng, Shirui;Xu, Guixing;Liang, Fanrong
通讯作者：
Liang, Fanrong
影响因子：
3.3
作者：
Lv Han;Zhao Pengfei;Wang Zhenchang
通讯作者：
Wang Zhenchang
影响因子：
3.5
作者：
Haraldsson, H.;Leach, J. R.;Amans, M. R.
通讯作者：
Amans, M. R.