Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface.
Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface.
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DOI：
10.1088/1741-2552/aa6801
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发表时间：
2017-06
影响因子：
4
通讯作者：
Bruns TM
中科院分区：
文献类型：
--
作者：
Khurram A;Ross SE;Sperry ZJ;Ouyang A;Stephan C;Jiman AA;Bruns TM
我们的目标是开发一个接口，集成慢性监测下尿路（LUT）的活动与刺激外周通路。在成年公猫骶神经背根节（DRG）植入穿透微电极。将外周电极放置在阴部神经、膀胱颈和尿道外括约肌附近。植入耻骨上膀胱导管进行生理盐水输注和压力监测。电极和导管导线封装在背面的外壳中。神经信号从微电极和膀胱压力的镇静或清醒的行为猫记录在各种测试条件下，每周一次。电极也被刺激以驱动活动。LUT单和多单位的活动记录了4至11周的四只猫。在每个实验中识别多达18个独特的膀胱压力单位。一些通道持续记录膀胱传入活动长达41天，我们连续跟踪单个单位长达23天。观察扩张诱发和刺激驱动（DRG和阴部）膀胱排空，在此期间记录LUT感觉活动。这种慢性植入动物模型允许LUT神经生理学的行为研究，并将允许继续开发用于膀胱控制的闭环神经假体。
Our goal is to develop an interface that integrates chronic monitoring of lower urinary tract (LUT) activity with stimulation of peripheral pathways. Penetrating microelectrodes were implanted in sacral dorsal root ganglia (DRG) of adult male felines. Peripheral electrodes were placed on or in the pudendal nerve, bladder neck and near the external urethral sphincter. Supra-pubic bladder catheters were implanted for saline infusion and pressure monitoring. Electrode and catheter leads were enclosed in an external housing on the back. Neural signals from microelectrodes and bladder pressure of sedated or awake-behaving felines were recorded under various test conditions in weekly sessions. Electrodes were also stimulated to drive activity. LUT single- and multi-unit activity was recorded for 4 to 11 weeks in four felines. As many as 18 unique bladder pressure single-units were identified in each experiment. Some channels consistently recorded bladder afferent activity for up to 41 days, and we tracked individual single-units for up to 23 days continuously. Distension-evoked and stimulation-driven (DRG and pudendal) bladder emptying was observed, during which LUT sensory activity was recorded. This chronic implant animal model allows for behavioral studies of LUT neurophysiology and will allow for continued development of a closed-loop neuroprosthesis for bladder control.
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影响因子：
4
作者：
Fisher, Lee E.;Ayers, Christopher A.;Gaunt, Robert A.
通讯作者：
Gaunt, Robert A.
DOI：
10.1016/1056-8719(94)90090-6
发表时间：
1994-12-01
影响因子：
1.9
作者：
HORVATH, G;MORVAY, Z;BENEDEK, G
通讯作者：
BENEDEK, G
影响因子：
2
作者：
Bruns, Tim M.;Weber, Douglas J.;Gaunt, Robert A.
通讯作者：
Gaunt, Robert A.
影响因子：
4
作者：
Holinski BJ;Everaert DG;Mushahwar VK;Stein RB
通讯作者：
Stein RB
影响因子：
4
作者：
Bruns, Tim M.;Gaunt, Robert A.;Weber, Douglas J.
通讯作者：
Weber, Douglas J.