Circadian misalignment increases mood vulnerability in simulated shift work.
Circadian misalignment increases mood vulnerability in simulated shift work.
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DOI：
10.1038/s41598-020-75245-9
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发表时间：
2020-10-29
影响因子：
4.6
通讯作者：
Scheer FAJL
中科院分区：
文献类型：
--
作者：
Chellappa SL;Morris CJ;Scheer FAJL
夜班工作可能会增加患抑郁症的风险。由于夜班工人的昼夜节律系统与日常睡眠-觉醒行为之间存在“失调”，对健康造成了负面影响，我们调查了在模拟轮班工作中，暴露于昼夜节律失调是否会导致情绪脆弱。我们在非轮班工人和轮班工人中进行了随机的受试者内交叉实验室研究。模拟夜班被用来诱导内源性昼夜起搏器和睡眠/觉醒周期之间的错位(昼夜错位)，同时控制环境条件和食物摄入量。昼夜节律失调对情绪状态产生不利影响，因此，在连续暴露于昼夜节律失调的4天中，非轮班工人的情绪和幸福感水平与昼夜节律失调时相比显著下降(与昼夜节律一致时相比，情绪：P <； 0.001；幸福感：P <； 0.001；调整后的p值)。同样，在倒班工人中，情绪和幸福感水平在错位的天数中显著降低，与昼夜节律对齐(“昼夜对齐条件”与“天”的相互作用，情绪：P = 0.002；幸福感：P = 0.002；调整后的p值)相比。我们的发现表明，昼夜节律失调是情绪易损性的重要生物学成分，从事倒班工作的人容易受到其有害情绪影响的影响。
Night shift work can associate with an increased risk for depression. As night workers experience a ‘misalignment’ between their circadian system and daily sleep–wake behaviors, with negative health consequences, we investigated whether exposure to circadian misalignment underpins mood vulnerability in simulated shift work. We performed randomized within-subject crossover laboratory studies in non-shift workers and shift workers. Simulated night shifts were used to induce a misalignment between the endogenous circadian pacemaker and sleep/wake cycles (circadian misalignment), while environmental conditions and food intake were controlled. Circadian misalignment adversely impacted emotional state, such that mood and well-being levels were significantly decreased throughout 4 days of continuous exposure to circadian misalignment in non-shift workers, as compared to when they were under circadian alignment (interaction of “circadian alignment condition” vs. “day”, mood: p < 0.001; well-being: p < 0.001; adjusted p-values). Similarly, in shift workers, mood and well-being levels were significantly reduced throughout days of misalignment, as compared to circadian alignment (interaction of “circadian alignment condition” vs. “day”, mood: p = 0.002; well-being: p = 0.002; adjusted p-values). Our findings indicate that circadian misalignment is an important biological component for mood vulnerability, and that individuals who engage in shift work are susceptible to its deleterious mood effects.
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影响因子：
2.8
作者：
Knutson KL;von Schantz M
通讯作者：
von Schantz M
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2.8
作者：
Folkard, Simon
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Folkard, Simon
影响因子：
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作者：
Chellappa, Sarah L.
通讯作者：
Chellappa, Sarah L.
影响因子：
5.6
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通讯作者：
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