Potency of fish collagen as a scaffold for regenerative medicine.
Potency of fish collagen as a scaffold for regenerative medicine.
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DOI：
10.1155/2014/302932
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发表时间：
2014
影响因子：
--
通讯作者：
Hayashi Y
中科院分区：
文献类型：
--
作者：
Yamada S;Yamamoto K;Ikeda T;Yanagiguchi K;Hayashi Y
细胞、生长因子和支架是组织工程的关键因素。近年来，由天然聚合物如胶原和明胶、生物可吸收的合成聚合物如聚乳酸和聚乙醇酸、无机材料如羟基磷灰石以及复合材料组成的支架得到了迅速发展。特别是胶原蛋白，由于其生物相容性和生物降解性，是最有前途的组织工程材料。胶原蛋白含有特定的细胞粘附结构域，包括精氨酸-甘氨酸-天冬氨酸（RGD）基序。在细胞表面上的整联蛋白受体与胶原分子上的RGD基序结合后，细胞粘附被主动诱导。这种相互作用有助于促进细胞生长和分化以及调节各种细胞功能。然而，由于其机械强度低，很难将纯胶原支架用作组织工程材料。为了弥补这一缺点，胶原蛋白支架通常使用交联剂进行改性，例如γ辐射和碳二亚胺。考虑到人畜共患病的可能性，各种最近的报告已经记录使用鱼胶原蛋白支架。我们在此回顾鱼胶原蛋白支架的潜力，以及相关的问题，以解决用于再生医学。
Cells, growth factors, and scaffold are the crucial factors for tissue engineering. Recently, scaffolds consisting of natural polymers, such as collagen and gelatin, bioabsorbable synthetic polymers, such as polylactic acid and polyglycolic acid, and inorganic materials, such as hydroxyapatite, as well as composite materials have been rapidly developed. In particular, collagen is the most promising material for tissue engineering due to its biocompatibility and biodegradability. Collagen contains specific cell adhesion domains, including the arginine-glycine-aspartic acid (RGD) motif. After the integrin receptor on the cell surface binds to the RGD motif on the collagen molecule, cell adhesion is actively induced. This interaction contributes to the promotion of cell growth and differentiation and the regulation of various cell functions. However, it is difficult to use a pure collagen scaffold as a tissue engineering material due to its low mechanical strength. In order to make up for this disadvantage, collagen scaffolds are often modified using a cross-linker, such as gamma irradiation and carbodiimide. Taking into account the possibility of zoonosis, a variety of recent reports have been documented using fish collagen scaffolds. We herein review the potency of fish collagen scaffolds as well as associated problems to be addressed for use in regenerative medicine.
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DOI：
10.1002/jbm.820240905
发表时间：
1990-09-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
HUANGLEE, LLH;CHEUNG, DT;NIMNI, ME
通讯作者：
NIMNI, ME
影响因子：
2.8
作者：
BROWM, JC;TIMPL, R
通讯作者：
TIMPL, R
影响因子：
14
作者：
Fujisato, T;Sajiki, T;Ikada, Y
通讯作者：
Ikada, Y
DOI：
10.1016/s0141-8130(03)00054-0
发表时间：
2003-09-01
影响因子：
8.2
作者：
Ikoma, T;Kobayashi, H;Mann, S
通讯作者：
Mann, S
影响因子：
5.2
作者：
Iohara, Koichiro;Zheng, Li;Nakashima, Misako
通讯作者：
Nakashima, Misako