Circular RNAs: New players involved in the regulation of cognition and cognitive diseases.
Circular RNAs: New players involved in the regulation of cognition and cognitive diseases.
复制标题
环状RNA：参与认知和认知疾病调节的新参与者
DOI：
10.3389/fnins.2023.1097878
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发表时间：
2023
影响因子：
4.3
通讯作者：
Wang, Yue
中科院分区：
文献类型：
--
作者：
Yu, Xiaohan;Liu, Haoyu;Chang, Ning;Fu, Weijia;Guo, Zhiwen;Wang, Yue
关键词：
环状RNA（Circular RNA，circRNA）是一类共价闭合的内源性单链RNA，被认为是基因异常剪接的副产物，不具有任何生物学功能。近年来，随着高通量测序和生物信息学的发展，人们发现了成千上万的circRNA及其不同的生物学功能。除了在确定circRNA在肿瘤进展、诊断和治疗中的作用方面取得了巨大进展外，越来越多的证据表明，circRNA在大脑中富集，特别是在突触中，并随着生物体的发育或衰老而动态变化。由于突触在高级认知功能中的特定作用，circRNA不仅可能在正常生理条件下参与认知功能，而且可能在其表达或定位异常调节后导致认知相关疾病。因此，在这篇综述中，我们总结了研究circRNA在认知功能中的作用，以及它们参与认知相关疾病，包括自闭症，抑郁症和阿尔茨海默病的发生，发展，预后和治疗的研究进展。
Circular RNAs (circRNAs), a type of covalently closed endogenous single-stranded RNA, have been regarded as the byproducts of the aberrant splicing of genes without any biological functions. Recently, with the development of high-throughput sequencing and bioinformatics, thousands of circRNAs and their differential biological functions have been identified. Except for the great advances in identifying circRNA roles in tumor progression, diagnosis, and treatment, accumulated evidence shows that circRNAs are enriched in the brain, especially in the synapse, and dynamically change with the development or aging of organisms. Because of the specific roles of synapses in higher-order cognitive functions, circRNAs may not only participate in cognitive functions in normal physiological conditions but also lead to cognition-related diseases after abnormal regulation of their expression or location. Thus, in this review, we summarized the progress of studies looking at the role of circRNA in cognitive function, as well as their involvement in the occurrence, development, prognosis, and treatment of cognitive-related diseases, including autism, depression, and Alzheimer’s diseases.
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影响因子：
14.9
作者：
Danan M;Schwartz S;Edelheit S;Sorek R
通讯作者：
Sorek R
影响因子：
--
作者：
Chen J;Zou Q;Lv D;Wei Y;Raza MA;Chen Y;Li P;Xi X;Xu H;Wen A;Zhu L;Tang G;Li M;Jiang A;Liu Y;Fu Y;Jiang Y;Li X
通讯作者：
Li X
影响因子：
14.9
作者：
Boccaletto P;Stefaniak F;Ray A;Cappannini A;Mukherjee S;Purta E;Kurkowska M;Shirvanizadeh N;Destefanis E;Groza P;Avşar G;Romitelli A;Pir P;Dassi E;Conticello SG;Aguilo F;Bujnicki JM
通讯作者：
Bujnicki JM
影响因子：
10.6
作者：
Berman, RM;Cappiello, A;Krystal, JH
通讯作者：
Krystal, JH
DOI：
10.1007/978-981-13-1426-1_3
发表时间：
2018-01-01
期刊：
CIRCULAR RNAS: BIOGENESIS AND FUNCTIONS
影响因子：
--
作者：
Aghaee-Bakhtiari, Seyed Hamid
通讯作者：
Aghaee-Bakhtiari, Seyed Hamid