T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom.
T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom.
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DOI：
10.1002/jmri.21957
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发表时间：
2009-11
影响因子：
4.4
通讯作者：
Reeder, Scott B.
中科院分区：
文献类型：
--
作者：
Hines, Catherine D. G.;Yu, Huanzhou;Shimakawa, Ann;McKenzie, Charles A.;Brittain, Jean H.;Reeder, Scott B.
关键词：
旨在确认T1独立、T2* 校正的脂肪定量技术，该技术在存在铁过载的情况下，在脂肪百分比和T2* 衰减的生理预期范围内，使用均匀脂肪-水-SPIO体模对脂肪进行准确的光谱建模。描述了一种由具有已知脂肪分数和铁浓度的小瓶组成的均匀凝胶体模。使用基于多回波化学位移的脂肪-水分离方法（IDEAL）进行脂肪分数成像，并进行各种重建以确定T2* 校正和精确光谱建模的影响。常规两点狄克逊（同相/异相）成像和MR波谱进行比较与已知的脂肪分数。当使用T2* 校正和精确的光谱建模时，发现在整个铁浓度范围内与已知脂肪分数的最佳一致性。传统的两点狄克逊成像严重低估了所有T2* 值的脂肪分数，特别是在较高的铁浓度。这项工作证明了T2* 校正和脂肪的准确光谱建模的必要性，以便使用MRI准确地量化脂肪。
To validate a T1-independent, T2*-corrected fat quantification technique that uses accurate spectral modeling of fat using a homogeneous fat-water-SPIO phantom over physiologically expected ranges of fat percentage and T2* decay in the presence of iron overload. A homogeneous gel phantom consisting of vials with known fat-fractions and iron concentrations is described. Fat-fraction imaging was performed using a multi-echo chemical shift-based fat-water separation method (IDEAL), and various reconstructions were performed to determine the impact of T2* correction and accurate spectral modeling. Conventional two-point Dixon (in-phase/out-of-phase) imaging and MR spectroscopy were performed for comparison with known fat-fractions. The best agreement with known fat-fractions over the full range of iron concentrations was found when T2* correction and accurate spectral modeling were used. Conventional two-point Dixon imaging grossly underestimated fat-fraction for all T2* values, but particularly at higher iron concentrations. This work demonstrates the necessity of T2* correction and accurate spectral modeling of fat in order to accurately quantify fat using MRI.
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