Cinnamaldehyde Could Reduce the Accumulation of Diarrhetic Shellfish Toxins in the Digestive Gland of the Mussel Perna viridis under Laboratory Conditions.
Cinnamaldehyde Could Reduce the Accumulation of Diarrhetic Shellfish Toxins in the Digestive Gland of the Mussel Perna viridis under Laboratory Conditions.
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实验室条件下肉桂醛可减少贻贝消化腺中腹泻性贝类毒素的积累
DOI：
10.3390/md19020063
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发表时间：
2021-01-27
期刊：
影响因子：
5.4
通讯作者：
Yang WD
中科院分区：
文献类型：
--
作者：
Duan GF;Liu Y;Zhang LN;Li HY;Liu JS;Yang WD
腹泻性贝类毒素（diarrheticshellbowtoxins，DST）是最重要的藻类毒素之一，分布于世界各地，通过食物链对人类健康构成巨大威胁。因此，寻找有效的方法减少贝类毒素积累具有重要意义。以产DST的利马原甲藻（Prorocentrum lima）为材料，研究了肉桂醛（CA）、槲皮素、冬凌草甲素和大蒜素对佩尔纳（Perna viridis）消化腺中DST积累的影响。结果表明，在4种植物化学物质中，CA能有效地降低大田软海绵酸当量（DSTs，okadaic acid-eq）在绿球藻消化腺中的积累。进一步的证据表明，CA可以减轻由DST引起的贻贝消化腺的组织学变化。RT-qPCR结果显示，CA可抑制DSTs对CYP 3A 4的诱导作用，提示CA诱导的DSTs减少可能与抑制CYP 3A 4的转录诱导有关。但在利用肉桂醛降低DSTs在田间的积累之前，还需进一步研究其作用机制、最佳处理时间、生态安全性和成本。
Diarrhetic shellfish toxins (DSTs), some of the most important phycotoxins, are distributed almost all over the world, posing a great threat to human health through the food chain. Therefore, it is of great significance to find effective methods to reduce toxin accumulation in shellfish. In this paper, we observed the effects of four phytochemicals including cinnamaldehyde (CA), quercetin, oridonin and allicin on the accumulation of DSTs in the digestive gland of Perna viridis after exposure to the DSTs-producing Prorocentrum lima. We found that, among the four phytochemicals, CA could effectively decrease the accumulation of DSTs (okadaic acid-eq) in the digestive gland of P. viridis. Further evidence demonstrated that CA could reduce the histological alterations of the digestive gland of a mussel caused by DSTs. RT-qPCR showed that CA could suppress the CYP3A4 induction by DSTs, suggesting that the DSTs’ decrease induced by CA might be related to the inhibition of CYP3A4 transcription induction. However, further studies on the underlying mechanism, optimal treatment time, ecological safety and cost should be addressed before cinnamaldehyde is used to decrease the accumulation of DSTs in field.
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