Temporal response of the human virome to immunosuppression and antiviral therapy.
Temporal response of the human virome to immunosuppression and antiviral therapy.
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DOI：
10.1016/j.cell.2013.10.034
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发表时间：
2013-11-21
期刊：
影响因子：
64.5
通讯作者：
Quake SR
中科院分区：
文献类型：
--
作者：
De Vlaminck I;Khush KK;Strehl C;Kohli B;Luikart H;Neff NF;Okamoto J;Snyder TM;Cornfield DN;Nicolls MR;Weill D;Bernstein D;Valantine HA;Quake SR
衡量免疫系统健康状况的实质性方法很少，而且免疫强度与微生物组病毒成分之间的联系知之甚少。器官移植受者接受结合免疫抑制和抗病毒药物的移植后治疗，为了解免疫调节对病毒组的影响提供了一个窗口。我们利用血浆中游离 DNA 的测序来研究一组器官移植受者（656 个样本，96 名患者）中的药物与病毒组的相互作用，发现抗病毒药物和免疫抑制剂强烈影响血浆中病毒组的结构。我们在治疗开始时观察到明显的病毒组组成动态，并发现总病毒载量随着免疫抑制而增加，而微生物组的细菌成分基本上不受影响。这些数据深入了解了人类病毒组、免疫系统状态和药物治疗效果之间的关系，并提供了病毒组状态预测免疫能力的潜在应用。
There are few substantive methods to measure the health of the immune system, and the connection between immune strength and the viral component of the microbiome is poorly understood. Organ transplant recipients are treated with a post-transplant therapy that combines immunosuppressive and antiviral drugs, offering a window into the effects of immune modulation on the virome. We used sequencing of cell-free DNA in plasma to investigate drug-virome interactions in a cohort of organ transplant recipients (656 samples, 96 patients), and find that antivirals and immunosuppressants strongly affect the structure of the virome in plasma. We observe marked virome compositional dynamics at the onset of the therapy and find that the total viral load increases with immunosuppression, whereas the bacterial component of the microbiome remains largely unaffected. The data provide insight into the relationship between the human virome, the state of the immune system, and the effects of pharmacological treatment, and offer a potential application of the virome state to predict immunocompetence.
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影响因子：
3.7
作者：
McElvania TeKippe E;Wylie KM;Deych E;Sodergren E;Weinstock G;Storch GA
通讯作者：
Storch GA
DOI：
10.1126/science.1198719
发表时间：
2011-05-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Gordon JI
影响因子：
6.4
作者：
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通讯作者：
Paya, CV
影响因子：
4.3
作者：
Avivi, I;Chakrabarti, S;MacKinnon, S
通讯作者：
MacKinnon, S
影响因子：
8.9
作者：
Stewart, S;Winters, GL;Billingham, ME
通讯作者：
Billingham, ME