Developmental changes in category-specific brain responses to numbers and letters in a working memory task.
Developmental changes in category-specific brain responses to numbers and letters in a working memory task.
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DOI：
10.1016/j.neuroimage.2008.10.027
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发表时间：
2009-02-15
期刊：
影响因子：
5.7
通讯作者：
Pelphrey KA
中科院分区：
文献类型：
--
作者：
Libertus ME;Brannon EM;Pelphrey KA
神经影像学研究已经确定了一个共同的网络的大脑区域，涉及前额叶和顶叶皮层在各种工作记忆（WM）的任务。然而，以前的研究也报道了该网络中的激活类别特异性解离。在这项研究中，我们研究了数字，字母和面孔的WM任务中类别特异性激活的发展。8岁的儿童和成人进行了2回WM任务，同时使用功能性磁共振成像（fMRI）测量他们的大脑活动。总体而言，儿童在所有三种WM条件下（数字，字母和面孔）的速度明显慢于成人，准确性也差;然而，在每个年龄组中，三种条件下的行为表现非常相似。功能磁共振成像结果显示，特定类别的激活成人，但不是儿童的顶内沟的数字条件。同样，在字母条件下，在成人中观察到类别特异性激活，但在左侧枕颞皮层中没有儿童。与此相反，儿童和成人表现出高度相似的大脑活动模式，在外侧梭状回解决2回WM任务与面部刺激。我们的研究结果表明，8岁的儿童还没有从事典型的大脑区域，已与抽象或语义处理的数字符号和字母时，这些过程是任务无关的，主要任务是苛刻的。然而，字母反应区域的大脑活动预测了儿童的拼写表现，强调了字母的抽象处理和语言能力之间的关系。最后，WM任务的行为表现是数学和语言能力的预测突出WM和其他认知能力之间的联系的发展。
Neuroimaging studies have identified a common network of brain regions involving the prefrontal and parietal cortices across a variety of working memory (WM) tasks. However, previous studies have also reported category-specific dissociations of activation within this network. In this study, we investigated the development of category-specific activation in a WM task with digits, letters, and faces. Eight-year-old children and adults performed a 2-back WM task while their brain activity was measured using functional magnetic resonance imaging (fMRI). Overall, children were significantly slower and less accurate than adults on all three WM conditions (digits, letters, and faces); however, within each age group, behavioral performance across the three conditions was very similar. FMRI results revealed category-specific activation in adults but not children in the intraparietal sulcus for the digit condition. Likewise, during the letter condition, category-specific activation was observed in adults but not children in the left occipital–temporal cortex. In contrast, children and adults showed highly similar brain-activity patterns in the lateral fusiform gyri when solving the 2-back WM task with face stimuli. Our results suggest that 8-year-old children do not yet engage the typical brain regions that have been associated with abstract or semantic processing of numerical symbols and letters when these processes are task-irrelevant and the primary task is demanding. Nevertheless, brain activity in letter-responsive areas predicted children’s spelling performance underscoring the relationship between abstract processing of letters and linguistic abilities. Lastly, behavioral performance on the WM task was predictive of math and language abilities highlighting the connection between WM and other cognitive abilities in development.
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影响因子：
1.5
作者：
Bull, R;Johnston, RS;Roy, JA
通讯作者：
Roy, JA
DOI：
10.1016/s0926-6410(00)00056-2
发表时间：
2001-01-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Druzgal, TJ;D'Esposito, M
通讯作者：
D'Esposito, M
影响因子：
5.7
作者：
CASEY, BJ;COHEN, JD;RAPOPORT, JL
通讯作者：
RAPOPORT, JL
影响因子：
9.8
作者：
Cantlon JF;Brannon EM;Carter EJ;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
1.5
作者：
Conklin, Heather M.;Luciana, Monica;Yarger, Rebecca S.
通讯作者：
Yarger, Rebecca S.