Physicochemical Properties of the Soluble Dietary Fiber from Laminaria japonica and Its Role in the Regulation of Type 2 Diabetes Mice.
Physicochemical Properties of the Soluble Dietary Fiber from Laminaria japonica and Its Role in the Regulation of Type 2 Diabetes Mice.
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DOI：
10.3390/nu14020329
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发表时间：
2022-01-13
期刊：
影响因子：
5.9
通讯作者：
Miao J
中科院分区：
文献类型：
--
作者：
Wang X;Zhang L;Qin L;Wang Y;Chen F;Qu C;Miao J
海带是一种大型海洋褐藻，每年产量很高。然而，由于其利用不足，其潜在价值被大大浪费。例如，在海藻胶生产过程中，大量海带纤维素未被使用。以海带副产物为原料制备可溶性膳食纤维（SDF），并探讨其理化性质。 SDF具有良好的保水、保油、吸水膨胀、葡萄糖和胆固醇吸收能力以及α-淀粉酶和α-葡萄糖苷酶的抑制活性。此外，SDF 对糖尿病小鼠的有益作用包括减轻体重、降低血糖和缓解胰岛素抵抗。最后，分别使用 16S 扩增子和 LC-MS/MS 分析粪便中的肠道菌群和代谢组产物。 SDF不仅显着改变了肠道菌群和肠道代谢物的组成和结构，而且显着增加了有益菌阿克曼氏菌、臭杆菌和拟杆菌的丰度，降低了有害菌葡萄球菌的丰度，增加了肠道内骆驼蓬碱、厚朴酚、花生四烯酸、前列腺素E2、尿瑞林和壬二酸等生物活性物质的含量。综上所述，这些研究结果表明膳食摄入SDF可缓解2型糖尿病疾病，并为SDF作为功能食品提供重要的理论依据。
Laminaria japonica is a large marine brown alga that is annually highly productive. However, due to its underutilization, its potential value is substantially wasted. For example, a lot of Laminaria japonica cellulose remains unused during production of algin. The soluble dietary fiber (SDF) was prepared from the byproducts of Laminaria japonica, and its physicochemical properties were explored. SDF exhibits good water-holding, oil-holding, water-absorbing swelling, glucose and cholesterol absorption capacity, and inhibitory activity of α-amylase and α-glucosidase. In addition, the beneficial effects of SDF in diabetic mice include reduced body weight, lower blood glucose, and relieved insulin resistance. Finally, the intestinal flora and metabolomic products were analyzed from feces using 16S amplicon and LC-MS/MS, respectively. SDF not only significantly changed the composition and structure of intestinal flora and intestinal metabolites, but also significantly increased the abundance of beneficial bacteria Akkermansia, Odoribacter and Bacteroides, decreased the abundance of harmful bacteria Staphylococcus, and increased the content of bioactive substances in intestinal tract, such as harmine, magnolol, arachidonic acid, prostaglandin E2, urimorelin and azelaic acid. Taken together, these findings suggest that dietary intake of SDF alleviates type 2 diabetes mellitus disease, and provides an important theoretical basis for SDF to be used as a functional food.
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DOI：
10.1515/hmbci-2013-0063
发表时间：
2014-01-01
影响因子：
1
作者：
Bradlow, H. Leon
通讯作者：
Bradlow, H. Leon
影响因子：
4.9
作者：
Kang, Yongbo;Li, Yu;Kong, Xiangyang
通讯作者：
Kong, Xiangyang
影响因子：
11.2
作者：
Liu, Huifan;Zeng, Xinyue;Ma, Lukai
通讯作者：
Ma, Lukai
影响因子：
6.1
作者：
Chen, Guijie;Xie, Minhao;Liu, Zhonghua
通讯作者：
Liu, Zhonghua
影响因子：
3.6
作者：
Ling, Zongxin;Kong, Jianming;Xiang, Charlie
通讯作者：
Xiang, Charlie