Neuronal pathways linking substance P to drug addiction and stress.
Neuronal pathways linking substance P to drug addiction and stress.
复制标题
DOI：
10.1016/j.brainres.2009.11.014
复制
发表时间：
2010-02-16
期刊：
影响因子：
2.9
通讯作者：
Commons, K. G.
中科院分区：
文献类型：
--
作者：
Commons, K. G.
越来越多的证据表明，神经肽P物质（SP）及其主要受体神经激肽1（NK1）在对阿片类药物和压力的行为反应中发挥特定作用，可能有助于启动和维持成瘾行为。在动物模型中，NK1受体是阿片类药物产生奖励和激励作用所必需的。SP神经传递也涉及对压力的行为反应和药物致敏过程，可能导致成瘾或复发的脆弱性。然而，SP神经传递在阿片介导的抗伤害感受和阿片耐受的发展中仅起次要作用。此外，SP对成瘾相关行为的影响对阿片类药物具有选择性，并且支持对可卡因或精神兴奋剂的反应的证据不那么令人信服。本文将综述SP神经传递对阿片依赖行为的影响，并将其与潜在的神经通路联系起来。具体而言，SP神经传递内的组件的基底前脑，特别是神经核和腹侧苍白球，以及在上升的血清素系统的行动将被强调。此外，阿片类药物和SP信号之间的细胞或网络水平的相互作用，可能是其关系的特异性的基础将进行审查。
Accumulating evidence suggests that the neuropeptide Substance P (SP), and it’s principal receptor neurokinin 1 (NK1), play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce their rewarding and motivational effects. SP neurotransmission is also implicated in the behavioral response to stress and in the process of drug sensitization, potentially contributing to vulnerability to addiction or relapse. However, SP neurotransmission only plays a minor role in opioid-mediated antinociception and the development of opioid tolerance. Moreover, the effects of SP on addiction-related behavior are selective for opioids and evidence supporting a role in the response to cocaine or psychostimulants is less compelling. This review will summarize the effects of SP neurotransmission on opioid-dependent behaviors and correlate them with potential contributing neural pathways. Specifically, SP neurotransmission within components of the basal forebrain particularly the nucleus accumbens and ventral pallidum as well as actions within the ascending serotonin system will be emphasized. In addition, cellular or network level interactions between opioids and SP signaling that may underlie the specificity of their relationship will be reviewed.
登录
查看更多内容
影响因子：
4.7
作者：
Carlezon WA Jr;Thomas MJ
通讯作者：
Thomas MJ
影响因子：
3.4
作者：
Auclair, A;Drouin, C;Tassin, JP
通讯作者：
Tassin, JP
影响因子：
5.3
作者：
Gadd, CA;Murtra, P;Hunt, SP
通讯作者：
Hunt, SP
影响因子：
3.3
作者：
Bell, MI;Richardson, PJ;Lee, K
通讯作者：
Lee, K
反应于物质P的背raphe核中局部副谷氨酸神经元包含囊泡谷氨酸转运蛋白3（VGLUT3）。
影响因子：
2.8
作者：
Commons KG
通讯作者：
Commons KG