Vasopressin and oxytocin responses to illusory self-motion and nausea in man.
Vasopressin and oxytocin responses to illusory self-motion and nausea in man.
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加压素和催产素对人类幻觉自我运动和恶心的反应。
DOI：
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发表时间：
1990
影响因子：
5.8
通讯作者：
R. Stern
中科院分区：
文献类型：
--
作者：
K. Koch;J. Summy;S. Bingaman;N. Sperry;R. Stern
加压素和催产素是神经垂体分泌的九肽;加压素的增加与某些物种（但不是所有物种）的恶心和呕吐有关。我们的目的是确定健康志愿者的血浆血管加压素和催产素水平是否发生了变化，这些志愿者在vection（一种产生自我运动错觉的视动刺激）期间是否发生了恶心。通过旋转一个内表面为黑色和白色垂直条纹的鼓，围绕坐着的静止受试者产生矢量。在整个实验过程中连续记录胃肌电活动，电极位于腹部表面。当出现恶心和胃速时，在注射前和转鼓旋转停止后采集血浆样品。从血浆中提取加压素和催产素，并通过RIA进行定量。在vection 6例受试者报告恶心和胃节律紊乱，其他6例受试者没有恶心，保持在正常的3-cpm肌电节律。各组受试者注射前的加压素和催产素值相似。停止注射后1分钟，出现恶心和胃速的受试者血浆加压素水平（35.4 +/- 26.7 pmol/L）显著高于无症状受试者（2.7 +/- 0.47 pmol/L）（P <0.05）。催产素水平没有变化，无论是vection或恶心。结论：1）在向量诱导的恶心和胃节律紊乱期间，大细胞-神经垂体系统中的加压素而不是催产素神经元被激活; 2）错觉性自我运动可以安全地用于研究人类脑-肠相互作用和恶心的神经内分泌反应。
Vasopressin and oxytocin are nonapeptides secreted from the neurohypophysis; increases in vasopressin are associated with nausea and vomiting in some, but not all, species. Our aim was to determine whether plasma vasopressin and oxytocin levels were altered in healthy volunteers who did or did not develop nausea during vection, an optokinetic stimulus which produces the illusion of self-motion. Vection was produced by rotating a drum with an inner surface of black and white vertical stripes around the seated stationary subject. Gastric myoelectrical activity was recorded continuously throughout the experiment with electrodes positioned on the abdominal surface. Plasma samples were obtained before vection and after drum rotation stopped when nausea and tachygastria were present. Vasopressin and oxytocin were extracted from plasma and quantified by RIA. During vection six subjects reported nausea and developed gastric dysrhythmias; six other subjects had no nausea and remained in normal 3-cpm myoelectrical rhythms. Vasopressin and oxytocin values before vection were similar in each group of subjects. One minute after vection stopped, plasma vasopressin levels were significantly greater (P less than 0.05) in subjects experiencing nausea and tachygastrias (35.4 +/- 26.7 pmol/L) than in those without symptoms (2.7 +/- 0.47 pmol/L). Oxytocin levels were unchanged by either vection or nausea. It is concluded that 1) vasopressin, not oxytocin, neurons in the magnocellular-neurohypophyseal system are activated during vection-induced nausea and gastric dysrhythmias; and 2) illusory self-motion may be used safely to study the neuroendocrine responses to brain-gut interactions and nausea in man.
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阿扑吗啡引起的人类恶心：加压素和胰多肽的释放。
影响因子：
29.4
作者：
Feldman,M;Samson,WK;O'Dorisio,TM
通讯作者：
O'Dorisio,TM
胆囊收缩素和胃扩张激活大鼠下丘脑中的催产素能细胞。
DOI：
10.1152/ajpregu.1987.253.4.r661
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Renaud,LP;Tang,M;McCann,MJ;Stricker,EM;Verbalis,JG
通讯作者：
Verbalis,JG
神经垂体分泌响应胆囊收缩素，但不响应人类膳食引起的胃扩张。
DOI：
10.1210/jcem-68-4-837
发表时间：
1989
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Miaskiewicz,SL;Stricker,EM;Verbalis,JG
通讯作者：
Verbalis,JG
抑制前列腺素合成对肾上腺素引起的人体胃十二指肠机电变化的影响。
影响因子：
8.9
作者：
Kim,CH;Hanson,RB;Abell,TL;Malagelada,JR
通讯作者：
Malagelada,JR
催产素和加压素的分泌响应刺激，产生大鼠习得性味觉厌恶。
影响因子：
1.9
作者：
Verbalis,JG;McHale,CM;Gardiner,TW;Stricker,EM
通讯作者：
Stricker,EM