Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats.
Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats.
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DOI：
10.1016/j.bbr.2012.06.003
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Rhodes, Michael E.
中科院分区：
文献类型：
--
作者：
Skwara, Amanda J.;Karwoski, Tracy E.;Czambel, R. Kenneth;Rubin, Robert T.;Rhodes, Michael E.
在本研究中，我们确定了环境富集（EE；Kong Toys® 和 Nestlets®）对雄性和雌性大鼠中单剂量尼古丁 (NIC) 的性异能 HPA 轴反应、连续 NIC 给药两周后的单剂量 NIC 以及单剂量美加明 (MEC) 的 NIC 戒断反应的影响。在 MEC 和 NIC 给药之前和之后进行血液采样，以确定促肾上腺皮质激素 (ACTH) 和皮质酮 (CORT)。支持和扩展了我们之前的发现，EE 似乎通过减少激素反应产生抗焦虑作用：与没有 EE 饲养的雄性和雌性大鼠相比，饲养 EE 的雄性和雌性大鼠的基线 ACTH 较低，并且 HPA 轴对注射盐水 (SAL) 轻度应激的反应显着较低。在许多男性和女性群体中，EE 降低了对单剂量 NIC、连续 NIC 和 MEC 诱导的 NIC 戒断的性异能反应。与男性 EE 组相比，女性 EE 组对连续 NIC 和 MEC 诱导的 NIC 戒断的 ACTH 反应减弱程度更大，表明女性对 EE 的抗焦虑作用更敏感。由于 EE 降低了大多数群体中 HPA 轴的应激反应激素，因此 EE 可能是减少 NIC 成瘾动物模型压力的有效干预措施。此外，EE 在 NIC 戒断的动物研究中的有效性可能会启发人类研究解决男性和女性的应对方式和戒烟问题。
In the present study, we determined the effects of environmental enrichment (EE; Kong Toys® and Nestlets®) on sexually diergic HPA axis responses to single-dose nicotine (NIC), single-dose NIC following continuous NIC administration for two weeks, and NIC withdrawal by single-dose mecamylamine (MEC) in male and female rats. Blood sampling occurred before and after MEC and NIC administrations for the determination of adrenocorticotropic hormone (ACTH) and corticosterone (CORT). Supporting and extending our previous findings, EE appeared to produce anxiolytic effects by reducing hormone responses: Male and female rats housed with EE had lower baseline ACTH and significantly lower HPA axis responses to the mild stress of saline (SAL) injection than did those housed without EE. The sexually diergic responses to single dose NIC, continuous NIC, and MEC-induced NIC withdrawal were reduced by EE in many male and female groups. ACTH responses to continuous NIC and MEC-induced NIC withdrawal were blunted to a greater extent in female EE groups than in male EE groups, suggesting that females are more sensitive to the anxiolytic effects of EE. Because EE lowered stress-responsive hormones of the HPA axis in most groups, EE may be a useful intervention for stress reduction in animal models of NIC addiction. As well, the effectiveness of EE in animal studies of NIC withdrawal may enlighten human studies addressing coping styles and tobacco cessation in men and women.
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影响因子：
4.1
作者：
AVISSAR, S;EGOZI, Y;SOKOLOVSKY, M
通讯作者：
SOKOLOVSKY, M
影响因子：
2.4
作者：
Chmiel, DJ;Noonan, M
通讯作者：
Noonan, M
影响因子：
--
作者：
Changeux, JP;Bertrand, D;Zoli, M
通讯作者：
Zoli, M
影响因子：
3.3
作者：
Al'Absi, Mustafa;Wittmers, Lorentz E.;Westra, Ruth
通讯作者：
Westra, Ruth
影响因子：
3.5
作者：
Angelucci, Francesco;De Bartolo, Paola;Petrosini, Laura
通讯作者：
Petrosini, Laura