Complex elaboration: making sense of meiotic cohesin dynamics.
Complex elaboration: making sense of meiotic cohesin dynamics.
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DOI：
10.1111/febs.13301
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Rankin S
中科院分区：
文献类型：
--
作者：
Rankin S
在有丝分裂的细胞中，从S期到分裂后期，粘着蛋白复合物将姐妹染色单体（DNA复制的产物）连接在一起。姐妹染色单体之间的凝聚力确保了染色体的精确分离，并促进了正常的基因调控和某些类型的DNA修复。在体细胞中，核心粘附素复合物由四个亚基组成：Smc 1，Smc 3，Rad21和SA亚基。在减数分裂细胞分裂减数分裂特异性异构体的几个凝聚素亚基也表达和纳入不同的减数分裂凝聚素复合物。这些减数分裂特异性形式的粘连蛋白在减数分裂进程中对染色体动力学的相对贡献还没有完全确定。然而，这些蛋白质在染色体配对和突触过程中的定位，以及它们独特的功能丧失表型，表明它们在控制减数分裂染色体行为中的作用不重叠。许多在有丝分裂过程中调节粘着蛋白功能的蛋白质似乎也在减数分裂过程中调节粘着蛋白。在这里，我们回顾如何有助于减数分裂的染色体动力学，并探讨在有丝分裂细胞周期和减数分裂进程中的粘附调节之间的异同。更深入地了解凝聚素在减数分裂中的调节和功能，将为凝聚素复合物如何在不同条件下促进不同类型的染色体相互作用提供重要的新见解。
In mitotically dividing cells, the cohesin complex tethers sister chromatids, the products of DNA replication, together from the time they are generated during S phase until anaphase. Cohesion between sister chromatids ensures accurate chromosome segregation, and promotes normal gene regulation and certain kinds of DNA repair. In somatic cells, the core cohesin complex is composed of four subunits: Smc1, Smc3, Rad21 and an SA subunit. During meiotic cell divisions meiosis-specific isoforms of several of the cohesin subunits are also expressed and incorporated into distinct meiotic cohesin complexes. The relative contributions of these meiosis-specific forms of cohesin to chromosome dynamics during meiotic progression have not been fully worked out. However, the localization of these proteins during chromosome pairing and synapsis, and their unique loss-of-function phenotypes, suggest non-overlapping roles in controlling meiotic chromosome behavior. Many of the proteins that regulate cohesin function during mitosis also appear to regulate cohesin during meiosis. Here we review how cohesin contributes to meiotic chromosome dynamics, and explore similarities and differences between cohesin regulation during the mitotic cell cycle and meiotic progression. A deeper understanding of the regulation and function of cohesin in meiosis will provide important new insights into how the cohesin complex is able to promote distinct kinds of chromosome interactions under diverse conditions.
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DOI：
10.1111/febs.13166
发表时间：
2015-07
期刊：
The FEBS journal
影响因子：
--
作者：
Gorbsky GJ
通讯作者：
Gorbsky GJ
影响因子：
4.4
作者：
Degner, Stephanie C.;Wong, Timothy P.;Jankevicius, Gytis;Feeney, Ann J.
通讯作者：
Feeney, Ann J.
DOI：
10.1083/jcb.200605074
发表时间：
2006-08-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ding DQ;Sakurai N;Katou Y;Itoh T;Shirahige K;Haraguchi T;Hiraoka Y
通讯作者：
Hiraoka Y
影响因子：
11.4
作者：
Eichinger, Christian S.;Kurze, Alexander;Nasmyth, Kim
通讯作者：
Nasmyth, Kim
影响因子：
9.2
作者：
Gerlich, Daniel;Koch, Birgit;Ellenberg, Jan
通讯作者：
Ellenberg, Jan