The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease.
The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease.
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DOI：
10.3389/fimmu.2021.732029
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发表时间：
2021
影响因子：
7.3
通讯作者：
Hotomi M
中科院分区：
文献类型：
--
作者：
Kono M;Nanushaj D;Sakatani H;Murakami D;Hijiya M;Kinoshita T;Shiga T;Kaneko F;Enomoto K;Sugita G;Miyajima M;Okada Y;Saika S;Hotomi M
瞬时受体电位（TRP）通道，广泛已知与热反应，疼痛诱导和炎症调节相关的神经元刺激，已在最近的研究中显示具有与炎症反应相关的潜在机制。TRP通道在细菌感染过程中对炎症环境的作用已被广泛证实。然而，它可能因通道/病原体的类型而异，并且尚不清楚TRP通道在肺炎球菌感染期间如何起作用。肺炎链球菌可引起严重感染，如肺炎、菌血症和脑膜炎，并伴有全身炎症反应。本研究探讨了TRP通道（TRPV 1和TRPV 4）的作用，肺炎球菌鼻腔定植和随后的发展侵袭性肺炎球菌疾病的小鼠模型。TRPV 1和TRPV 4通道都被证明与肺炎球菌疾病的发展有关。特别是，在TRPV 4敲除小鼠中，鼻腔中嗜中性粒细胞（多形核细胞）的流入和杀菌活性被显著抑制。这可能导致严重的肺炎球菌肺炎，导致细菌传播到各种器官，并在流感病毒合并感染期间造成高死亡率。通过TRP通道调节宿主免疫反应可能是对抗引起强烈局部/全身炎症的病原微生物的新策略。
Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies to have underlying mechanisms associated with inflammatory responses. The role of TRP channels on inflammatory milieu during bacterial infections has been widely demonstrated. It may vary among types of channels/pathogens, however, and it is not known how TRP channels function during pneumococcal infections. Streptococcus pneumoniae can cause severe infections such as pneumonia, bacteremia, and meningitis, with systemic inflammatory responses. This study examines the role of TRP channels (TRPV1 and TRPV4) for pneumococcal nasal colonization and subsequent development of invasive pneumococcal disease in a mouse model. Both TRPV1 and TRPV4 channels were shown to be related to regulation of the development of pneumococcal diseases. In particular, the influx of neutrophils (polymorphonuclear cells) in the nasal cavity and the bactericidal activity were significantly suppressed among TRPV4 knockout mice. This may lead to severe pneumococcal pneumonia, resulting in dissemination of the bacteria to various organs and causing high mortality during influenza virus coinfection. Regulating host immune responses by TRP channels could be a novel strategy against pathogenic microorganisms causing strong local/systemic inflammation.
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影响因子：
--
作者：
Samanta A;Hughes TET;Moiseenkova-Bell VY
通讯作者：
Moiseenkova-Bell VY
影响因子：
--
作者：
Smith AM;McCullers JA
通讯作者：
McCullers JA
影响因子：
6
作者：
Rajan S;Schremmer C;Weber J;Alt P;Geiger F;Dietrich A
通讯作者：
Dietrich A
DOI：
10.4049/jimmunol.1400133
发表时间：
2014-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Das R;LaRose MI;Hergott CB;Leng L;Bucala R;Weiser JN
通讯作者：
Weiser JN
影响因子：
4.8
作者：
Suzuki, M;Mizuno, A;Imai, M
通讯作者：
Imai, M