Smoked cannabis reduces peak cocaine plasma levels and subjective effects in a controlled drug administration study of polysubstance use in men.
Smoked cannabis reduces peak cocaine plasma levels and subjective effects in a controlled drug administration study of polysubstance use in men.
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DOI：
10.1016/j.drugalcdep.2022.109757
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发表时间：
2023-02-01
影响因子：
4.2
通讯作者：
Cooper, Ziva D.
中科院分区：
文献类型：
--
作者：
Murray, Conor H.;Haney, Margaret;Foltin, Richard W.;Manubay, Jeanne;Bedi, Gillinder;Cooper, Ziva D.
尽管多物质使用的流行率很高，但与常见药物组合相关的结果和潜在风险并没有很好地表征。许多使用可卡因的人同时也使用大麻，但人们对这两种药物之间的相互作用如何可能导致持续的共同使用知之甚少。这项双盲、安慰剂对照研究的目的是确定吸食大麻和吸食可卡因的生理和主观影响，以确定可能导致这种药物组合持续使用的变量。健康的、不寻求治疗的志愿者（N = 9，所有男性）报告吸食可卡因和大麻，完成了为期13天的住院治疗方案。在治疗日，大麻[0.0或5.6%四氢大麻酚（THC）]比可卡因（0、12或25毫克）早给药28分钟。依赖测量包括四氢大麻酚和可卡因及其各自代谢物的药代动力学评估，以及主观和心血管效应。活性大麻（5.6% THC）增加了血浆中THC和代谢物11-no -9-羧基-Δ9-THC （THCCOOH）的水平，以及相对于非活性大麻对大麻效果和心率的主观评分。可卡因剂量依赖性增加血浆可卡因和代谢物以及可卡因效应的主观评分。活性大麻预处理降低了血浆可卡因和代谢物水平。此外，活性大麻减弱了与可卡因有关的“饥饿”和“平静”的减少。“大麻预处理改变了吸食可卡因的主观体验，降低了可卡因的血浆峰值水平。未来的研究应该探索每种药物的额外剂量，以及这些变化是否也会影响可卡因的强化作用。
Despite the high prevalence of polysubstance use, outcomes and potential risks associated with common drug combinations are not well characterized. Many individuals who use cocaine also use cannabis, yet little is known about how interactions between the two drugs might contribute to continued co-use. The aim of this double-blind, placebo-controlled study was to determine the physiological and subjective effects of smoked cannabis with smoked cocaine, to identify variables that may contribute to the continued use of this drug combination. Healthy, non-treatment seeking volunteers who reported smoking both cocaine and cannabis (N = 9, all males) completed a 13-day inpatient protocol. On session days, cannabis [0.0 or 5.6 % tetrahydrocannabinol (THC)] was administered 28 min prior to cocaine (0, 12, or 25 mg). Dependent measures included pharmacokinetic assessment of THC and cocaine and their respective metabolites, in addition to subjective and cardiovascular effects. Active cannabis (5.6 % THC) increased plasma levels of THC and the metabolite 11-nor-9-carboxy-Δ9-THC (THCCOOH), as well as subjective ratings of cannabis effects and heart rate relative to inactive cannabis. Cocaine dose-dependently increased plasma cocaine and metabolites and subjective ratings of cocaine effects. Active cannabis pre-treatment decreased plasma levels of cocaine and metabolites. Furthermore, active cannabis attenuated cocaine-related reductions in ‘Hunger’ and ‘Calm.’ Cannabis pre-treatment altered the subjective experience of smoked cocaine and reduced peak plasma levels of cocaine. Future studies should explore additional doses of each drug and whether these changes also impact cocaine’s reinforcing effects.
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影响因子：
10.6
作者：
Haney, Margaret;Gunderson, Erik W.;Jiang, Huiping;Collins, Eric D.;Foltin, Richard W.
通讯作者：
Foltin, Richard W.
影响因子：
4.7
作者：
Araque A;Castillo PE;Manzoni OJ;Tonini R
通讯作者：
Tonini R
影响因子：
4.2
作者：
FOLTIN, RW;FISCHMAN, MW;PEARLSON, GD
通讯作者：
PEARLSON, GD
影响因子：
7.6
作者：
Haney, Margaret;Hart, Carl L.;Foltin, Richard W.
通讯作者：
Foltin, Richard W.
影响因子：
3.6
作者：
Foltin, Richard W.;Haney, Margaret;Evans, Suzette M.
通讯作者：
Evans, Suzette M.