Brain lesion volume and neuropsychological function predict efficacy of treatment for depression in multiple sclerosis.
Brain lesion volume and neuropsychological function predict efficacy of treatment for depression in multiple sclerosis.
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脑损伤体积和神经心理功能可预测多发性硬化症抑郁症的治疗效果。
DOI：
10.1037/0022-006x.71.6.1017
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发表时间：
2003
影响因子：
5.9
通讯作者：
Nelson,Sarah
中科院分区：
文献类型：
--
作者：
Mohr,DavidC;Epstein,Lucy;Luks,TracyL;Goodkin,Donald;Cox,Darcy;Goldberg,Alison;Chin,Cynthia;Nelson,Sarah
本研究探讨了多发性硬化症（MS）和抑郁症（MDD）共病患者的脑损伤和神经心理学损害对抑郁症治疗效果的影响。30例符合MS和MDD标准的患者接受了3次16周抑郁治疗中的1次，并在治疗停止后随访6个月。T2加权磁共振成像和神经心理学评估也获得了。治疗结束时贝克抑郁量表（BDI; AT Beck，CH Ward，M. Mendelson，J. Mock，& J. Erbaugh，1961）基线BDI的残差结果与右颞侧脑室周围病变体积相关（R2= 0. 32，p=. 002)左颞叶灰白交界区病变体积（R2=. 19，p=. 02)但与任何其他脑区的病变体积或神经心理功能无统计学相关性。通过总病变体积预测6个月随访时的BDI结果（残差为治疗结束时的BDI）（R2=. 22，p=. 005），病变体积在许多离散的领域，和神经心理功能（R2=。29，p=. 0009）。总病变体积对6个月随访BDI结果的影响完全由神经心理功能介导。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
This study examined the effects of brain lesions and neuropsychological impairment on the efficacy of treatment for depression in patients with comorbid diagnoses of multiple sclerosis (MS) and major depressive disorder (MDD). Thirty patients meeting criteria for MS and MDD received 1 of 3 16-week treatments for depression and were followed for 6 months following treatment cessation. T2-weighted magnetic resonance imaging and neuropsychological evaluations were also obtained. End-of-treatment Beck Depression Inventory (BDI; AT Beck, CH Ward, M. Mendelson, J. Mock, & J. Erbaugh, 1961) results residualized for baseline BDI were related to right temporal periventricular lesion volume (R2=. 32, p=. 002) and left temporal grey-white junction lesion volume (R2=. 19, p=. 02) but were not statistically related to lesion volume in any other brain region or to neuropsychological function. BDI results at 6-month follow-up, residualized for end-of-treatment BDI, were predicted by total lesion volume (R2=. 22, p=. 005), lesion volume in many discrete areas, and neuropsychological functioning (R2=. 29, p=. 0009). The effect of total lesion volume on 6-month follow-up BDI results was fully mediated by neuropsychological function.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
多发性硬化症的新诊断标准
影响因子：
9.9
作者：
H. Petereit;Wolf D Heiss
通讯作者：
Wolf D Heiss
影响因子：
5.8
作者：
Berg, D;Supprian, T;Becker, G
通讯作者：
Becker, G
是否存在可预测多发性硬化症患者痴呆的特定 MRI 结果？
影响因子：
--
作者：
F. Patti;M. Di Stefano;D. de Pascalis;M. Ciancio;E. de Bernardis;F. Nicoletti;A. Reggio
通讯作者：
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多发性硬化症患者解决问题的威斯康星州和加利福尼亚州卡片分类测试的表现比较
影响因子：
2.6
作者：
W. Beatty;N. Monson
通讯作者：
N. Monson