Haplotypes that are mosaic for wild-type and t complex-specific alleles in wild mice.
Haplotypes that are mosaic for wild-type and t complex-specific alleles in wild mice.
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野生型小鼠中野生型和 t 复合体特异性等位基因的嵌合单倍型。
DOI：
10.1093/genetics/123.2.405
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发表时间：
1989
期刊：
影响因子：
3.3
通讯作者：
Nadeau,JH
中科院分区：
文献类型：
--
作者：
Erhart,MA;Phillips,SJ;Bonhomme,F;Boursot,P;Wakeland,EK;Nadeau,JH
两个突出的问题有关的人口动态和演变的t复合体在小鼠关注的t单倍型在野生和这些单倍型重组与野生型同源的程度的频率。为了解决这些问题，估计野生小鼠中几种t复合物相关限制性片段变体的频率和分布。64个版本的17号染色体从野生小家鼠和小家鼠的小家鼠的DNA探针进行了检查，为6个位点内的t复杂的，表现出限制性片段的变化。所有六种探针都能检测到迄今为止只发现与t复合体相关的变异。单倍型分析的野生衍生染色体揭示了高频率（45.3%）的“马赛克”单倍型的混合物的t-特异性和野生型的变体和只有一个单倍型与t-特异性的变体在所有六个位点。当12个良好的特点，从不同的地理区域分离的t单倍型进行了分析，只有三个有一套完整的t特异性限制性片段的6个位点的检查。嵌合单倍型在两组小鼠中的优势可以通过以下假设中的任何一种来解释：t单倍型和它们的野生型同源物之间的遗传重组，从祖先部分t单倍型下降的单倍型在野生种群中的持续存在，或者固定在祖先t单倍型中的限制性片段变体也固定在一些野生型单倍型中。在我们的数据中有证据支持所有这三个假设。一些嵌合单倍型的等位基因组成表明，它们可能是通过节段重组形成的，无论是双交换还是基因转换，而不是简单的单交换。在两种M. M. musculus和M. M.这表明这些单倍型是祖先的，而不是最近衍生的。
Two outstanding problems pertaining to the population dynamics and evolution of the t complex in mice concern the frequency of t haplotypes in the wild and the degree to which these haplotypes recombine with their wild-type homologs. To address these problems, the frequency and distribution of several t complex-associated restriction fragment variants in wild mice were estimated. Sixty-four versions of chromosome 17 from wild-derived Mus musculus musculus and Mus musculus domesticus were examined with DNA probes for six loci within the t complex that exhibit restriction fragment variation. All six probes detect variants that have heretofore been found exclusively associated with the t complex. Haplotype analysis of wild-derived chromosomes revealed a high frequency (45.3%) of "mosaic" haplotypes with a mixture of t-specific and wild-type variants and only one haplotype with t-specific variants at all six loci. When 12 well-characterized t haplotypes isolated from diverse geographic regions were analyzed, only three had a complete set of t-specific restriction fragments for the six loci examined. The preponderance of mosaic haplotypes in both groups of mice can be explained by any one of the following hypotheses: genetic recombination between t haplotypes and their wild-type homologs, the persistence in wild populations of haplotypes that have descended from ancestral partial t haplotypes, or that the restriction fragment variants fixed in the ancestral t haplotype were also fixed in some wild-type haplotypes. There is evidence to support all three of these hypotheses in our data. The allelic composition of some mosaic haplotypes indicates that they may have been formed by segmental recombination, either double crossing over or gene conversion, rather than by simple single crossovers. The occurrence of indistinguishable mosaic haplotypes in both M. m. musculus and M. m. domesticus suggests that these haplotypes are ancestral rather than recently derived.
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影响因子：
3.3
作者：
Artzt,K;Cookingham,J;Bennett,D
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
64.8
作者：
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