BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R.
BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R.
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DOI：
10.1093/bioinformatics/btab121
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发表时间：
2021-08-25
期刊：
影响因子：
--
通讯作者：
Chaussabel D
中科院分区：
文献类型：
--
作者：
Rinchai D;Roelands J;Toufiq M;Hendrickx W;Altman MC;Bedognetti D;Chaussabel D
We previously described the construction and characterization of fixed reusable blood transcriptional module repertoires. More recently we released a third iteration (‘BloodGen3’ module repertoire) that comprises 382 functionally annotated modules and encompasses 14 168 transcripts. Custom bioinformatic tools are needed to support downstream analysis, visualization and interpretation relying on such fixed module repertoires. We have developed and describe here an R package, BloodGen3Module. The functions of our package permit group comparison analyses to be performed at the module-level, and to display the results as annotated fingerprint grid plots. A parallel workflow for computing module repertoire changes for individual samples rather than groups of samples is also available; these results are displayed as fingerprint heatmaps. An illustrative case is used to demonstrate the steps involved in generating blood transcriptome repertoire fingerprints of septic patients. Taken together, this resource could facilitate the analysis and interpretation of changes in blood transcript abundance observed across a wide range of pathological and physiological states. The BloodGen3Module package and documentation are freely available from Github: https://github.com/Drinchai/BloodGen3Module. Supplementary data are available at Bioinformatics online.
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影响因子：
30.5
作者：
Alsina, Laia;Israelsson, Elisabeth;Altman, Matthew C.;Dang, Kristen K.;Ghandil, Pegah;Israel, Laura;von Bernuth, Horst;Baldwin, Nicole;Qin, Huanying;Jin, Zongbo;Banchereau, Romain;Anguiano, Esperanza;Ionan, Alexei;Abel, Laurent;Puel, Anne;Picard, Capucine;Pascual, Virginia;Casanova, Jean Laurent;Chaussabel, Damien
通讯作者：
Chaussabel, Damien
WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
影响因子：
10.6
作者：
Rinchai D;Altman MC;Konza O;Hässler S;Martina F;Toufiq M;Garand M;Kabeer BSA;Palucka K;Mejias A;Ramilo O;Bedognetti D;Mariotti-Ferrandiz E;Klatzmann D;Chaussabel D
通讯作者：
Chaussabel D
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
32.4
作者：
Obermoser, Gerlinde;Presnell, Scott;Chaussabel, Damien
通讯作者：
Chaussabel, Damien