Innovative Strategies in Tendon Tissue Engineering.
Innovative Strategies in Tendon Tissue Engineering.
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DOI：
10.3390/pharmaceutics13010089
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发表时间：
2021-01-11
期刊：
影响因子：
5.4
通讯作者：
Ferrari F
中科院分区：
文献类型：
--
作者：
Bianchi E;Ruggeri M;Rossi S;Vigani B;Miele D;Bonferoni MC;Sandri G;Ferrari F
肌腱是一种高度定向的结缔组织，它将力从肌肉传递到骨骼。每年，据报道有超过3200万例肌腱损伤。事实上，肌腱病至少占所有运动损伤的50%，并且由于人口老龄化，其发病率在近几十年有所增加。目前用于肌腱治疗的临床移植物受到多种限制，对替代性工程组织有很大需求。因此，需要探索创新策略。肌腱替代和再生是复杂的，因为支架需要保证足够的分级结构形态和力学性能以承受负荷。此外，为了引导细胞增殖和生长，支架应提供一个模拟肌腱细胞外基质中胶原蛋白排列的纤维网络。这篇综述聚焦于肌腱修复和再生。特别关注了组织工程中的创新方法。描述了先进的制造技术，如静电纺丝、软光刻和三维（3D）打印。此外，还考虑了生物增强，这是一种具有巨大治疗潜力的新兴策略。
The tendon is a highly aligned connective tissue that transmits force from muscle to bone. Each year, more than 32 million tendon injuries have been reported, in fact, tendinopathies represent at least 50% of all sports injuries, and their incidence rates have increased in recent decades due to the aging population. Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. For this reason, innovative strategies need to be explored. Tendon replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology and mechanical properties to stand the load. Moreover, to guide cell proliferation and growth, scaffolds should provide a fibrous network that mimics the collagen arrangement of the extracellular matrix in the tendons. This review focuses on tendon repair and regeneration. Particular attention has been devoted to the innovative approaches in tissue engineering. Advanced manufacturing techniques, such as electrospinning, soft lithography, and three-dimensional (3D) printing, have been described. Furthermore, biological augmentation has been considered, as an emerging strategy with great therapeutic potential.
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DOI：
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