Chronic stress, energy balance and adiposity in female rats.
Chronic stress, energy balance and adiposity in female rats.
复制标题
DOI：
10.1016/j.physbeh.2010.09.024
复制
发表时间：
2011-01-10
影响因子：
2.9
通讯作者：
Herman, James P.
中科院分区：
文献类型：
--
作者：
Solomon, Matia B.;Jankord, Ryan;Flak, Jonathan N.;Herman, James P.
压力会优先增加女性对高脂肪食物的摄入量，这表明这两个因素的交互作用可能会不成比例地使女性更容易超重。在本研究中，雌性大鼠暴露于慢性高脂饮食或饮食，并暴露于4周的慢性可变应激(CVS)或作为家庭笼养对照组。与所有组相比，暴露于高脂肪饮食的对照组女性表现出许多代谢综合征的症状，包括体重增加、总脂肪和内脏脂肪以及胰岛素和瘦素浓度的增加。然而，CVS-高脂组、CVS-食物组和对照组的体重增加和热量效率相似。这一发现表明，与喂食标准饮食的女性相比，接受高脂肪饮食的女性CVS增加的能量消耗要多得多。CVS-高脂组肥胖增加，循环瘦素和胰岛素浓度增加，尽管他们的体重与对照组没有差异。由于压力的影响与高脂肪摄入量在确定体重时相互作用，我们的结果强调了评估肥胖程度的重要性，而不仅仅是体重，作为整体代谢健康的指标。总体而言，数据表明，在雌性大鼠中，与喂食食物的雌性大鼠相比，长期应激可以防止高脂饮食导致的体重增加，但并不能阻止高脂饮食导致的肥胖增加。
Stress preferentially increases the consumption of high-fat foods in women, suggesting the interaction of these two factors may disproportionately predispose women toward excess weight gain. In the present study, female rats were exposed to a chronic high-fat or chow diet and were exposed to 4 weeks of chronic variable stress (CVS) or served as home cage controls. Control females exposed to a high-fat diet displayed many symptoms of the metabolic syndrome including increased body weight gain, total and visceral adiposity and insulin and leptin concentrations relative to all groups. However, CVS-high fat, CVS-chow and control chow groups had similar body weight gain and caloric efficiency. This finding suggests that CVS increases energy expenditure much more in females exposed to a high-fat diet relative to those fed a standard chow diet. The CVS-high fat group had increased adiposity and increased circulating leptin and insulin concentrations, despite the fact that their body weight did not differ from controls. As the effect of stress interacts with high-fat consumption in determining body weight, our results underscore the importance of assessing the degree of adiposity, rather than body weight alone, as an index of overall metabolic health. Overall, the data indicate that in female rats, chronic stress prevents high-fat diet related increases in body weight, but does not prevent high-fat diet induced increases in adiposity when compared to chow-fed females.
登录
查看更多内容
保护雌性斯普拉格道利大鼠免受高脂肪饮食引起的糖耐量受损
影响因子：
2
作者：
Lu, Zhongyan;Wang, Zhe;Gan, Lixia
通讯作者：
Gan, Lixia
影响因子：
6.9
作者：
Priego, Teresa;Sanchez, Juana;Palou, Andreu
通讯作者：
Palou, Andreu
影响因子：
4.8
作者：
Ulrich-Lai, Yvonne M.;Ostrander, Michelle M.;Herman, James P.
通讯作者：
Herman, James P.
影响因子：
5.8
作者：
WAJCHENBERG, BL;BOSCO, A;LIBERMAN, B
通讯作者：
LIBERMAN, B
影响因子：
4.8
作者：
Pecoraro, N;Reyes, F;Dallman, MF
通讯作者：
Dallman, MF