Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth.
Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth.
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DOI：
10.1038/s41398-022-02013-w
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发表时间：
2022-08-10
影响因子：
6.8
通讯作者：
Pittenger, Christopher
中科院分区：
文献类型：
--
作者：
Grazioplene, Rachael G.;DeYoung, Colin G.;Hampson, Michelle;Anticevic, Alan;Pittenger, Christopher
强迫症状（OCS）在学龄儿童中很常见，可以预测强迫症（OCD）的发展。在强迫症中已经有白质异常的描述，但是在发育中的大脑中白质与强迫症的相关性尚不清楚。强迫症的一些相关因素（或强迫症的诊断）可能反映了一个跨诊断甚至一般的精神病理因素的相关。我们在一个典型发展青年（N = 1208）的大样本中检验了这些问题，使用基于固定的白质测量与OCS和一般精神病理学相关的分层分析。一般精神病理与后胼胝体和大钳的异常有关，并以年龄依赖的方式显示成熟改变（特别是年轻受试者的过度成熟）。OCS的单维测量与任何白质异常无关，但单独的OCS维度分析（来自该样本中的因子分析）显示，“坏想法”维度与顶叶背白质和下行皮质脊髓束的白质异常有关，“对称”维度与胼胝体前部的异常有关。重复/检查和对称OCS还与后部异常相关，与一般精神病理相关重叠。污染症状与白质无关。分数各向异性（FA）的二次分析显示了明显的白质异常，表明基于固定细胞和FA的分析确定了与精神病理相关的白质的不同特征。这些发现表明OCS维度与白质中可分离异常相关，暗示可分离网络。未来的研究应该在纵向框架中检查这些白质特征。
Obsessive-compulsive symptoms (OCS) are common in school-aged children and predict the development of obsessive compulsive disorder (OCD). White-matter abnormalities have been described in OCD, but the white matter correlates of OCS in the developing brain are unclear. Some correlates of OCS (or a diagnosis of OCD) may reflect correlates of a transdiagnostic or even general psychopathology factor. We examined these questions in a large sample of typically developing youth (N = 1208), using a hierarchical analysis of fixel-based white matter measures in relation to OCS and general psychopathology. General psychopathology was associated with abnormalities in the posterior corpus callosum and forceps major in an age-dependent manner, suggesting altered maturation (specifically, hypermaturation in younger subjects). A unidimensional measure of OCS did not associate with any white-matter abnormalities, but analysis of separate OCS dimensions (derived from factor analysis within this sample) revealed the ‘Bad Thoughts’ dimension to associate with white-matter abnormalities in dorsal parietal white-matter and descending corticospinal tracts, and the ‘Symmetry’ dimension to associate with abnormalities in the anterior corpus callosum. Repetition/checking and Symmetry OCS were additionally associated with posterior abnormalities overlapping with the correlates of general psychopathology. Contamination symptoms had no white-matter correlates. Secondary analysis of fractional anisotropy (FA) revealed distinct white-matter abnormalities, suggesting that fixel-based and FA analyses identify distinct features of white matter relevant to psychopathology. These findings suggest that OCS dimensions correlate with dissociable abnormalities in white matter, implicating separable networks. Future studies should examine these white-matter signatures in a longitudinal framework.
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DOI：
10.1016/j.jaac.2018.06.038
发表时间：
2019-02-01
影响因子：
13.3
作者：
Barzilay, Ran;Patrick, Ariana;Gur, Raquel E.
通讯作者：
Gur, Raquel E.
影响因子：
6.9
作者：
Li W;Lai TM;Bohon C;Loo SK;McCurdy D;Strober M;Bookheimer S;Feusner J
通讯作者：
Feusner J
DOI：
10.1176/appi.ajp.2008.08020320
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bloch MH;Landeros-Weisenberger A;Rosario MC;Pittenger C;Leckman JF
通讯作者：
Leckman JF
影响因子：
4.5
作者：
Kobayashi, Hiroyuki;Nemoto, Takahiro;Mizuno, Masafumi
通讯作者：
Mizuno, Masafumi
影响因子：
3.1
作者：
Kessler, Ronald C.;Petukhova, Maria;Sampson, Nancy A.;Zaslavsky, Alan M.;Wittchen, Hans-Ullrich
通讯作者：
Wittchen, Hans-Ullrich