Novel Findings of Retinal and Choroidal Features Utilizing Optical Coherence Tomography Angiography Analysis in Patients With Autoimmune Posterior Uveitis.
Novel Findings of Retinal and Choroidal Features Utilizing Optical Coherence Tomography Angiography Analysis in Patients With Autoimmune Posterior Uveitis.
复制标题
利用光学相干断层扫描血管造影分析自身免疫性后葡萄膜炎患者的视网膜和脉络膜特征的新发现。
DOI：
10.3389/fmed.2021.801036
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发表时间：
2021
影响因子：
3.9
通讯作者：
Feng L
中科院分区：
文献类型：
--
作者：
Shen J;Kong J;Chen S;Liu X;Teng Y;Wu H;Wang L;Wu M;Su Z;Feng L
目的：分析自身免疫性后葡萄膜炎患者光学相干断层扫描血管造影（OCTA）的定量参数。方法：对65例葡萄膜炎患者和65例正常对照眼进行OCTA检查。比较急性葡萄膜炎眼、慢性葡萄膜炎眼和正常对照眼的黄斑中心厚度（CMT）、视网膜厚度、中心凹无血管区（FAZ）面积、中心凹密度300 μm（FD 300）和血管密度（VD）。在脉络膜毛细血管、外视网膜、视盘、全层和旁浅层毛细血管丛（SCP）以及全层和旁深层毛细血管丛（DCP）中评估VD。采用相关分析法分析LogMAR最佳矫正视力（BCVA）与OCTA定量参数的关系。结果：与正常眼相比，葡萄膜炎眼的CMT和视网膜厚度显著增加（P < 0.05）。在FAZ区域未观察到显著差异。葡萄膜炎眼的FD300、视盘VD、全像、旁像、脉络膜毛细血管的SCP、DCP均较NC眼显著降低（P < 0.05），仅急性组外视网膜和脉络膜毛细血管的VD较NC眼显著降低（P < 0.05）。葡萄膜炎患者OCTA定量参数与LogMAR BCVA显著相关。全VD DCP是葡萄膜炎患者BCVA的最佳预测因子。结论：OCTA定量测量是客观评估自身免疫性后葡萄膜炎的一种有前途的策略。
Purpose: To analyze the quantitative parameters acquired by optical coherence tomography angiography (OCTA) in patients with autoimmune posterior uveitis. Methods: OCTA images of 65 eyes affected with uveitis and 65 normal control (NC) eyes were obtained. The central macular thickness (CMT), retinal thicknesses, foveal avascular zone (FAZ) area, foveal density 300 μm (FD300), and vascular density (VD) were compared among acute uveitic eyes, chronic uveitic eyes, and NC eyes. VDs were evaluated in the choriocapillaris, outer retina, optic disk, whole and parafovea superficial capillary plexus (SCP), and whole and parafovea deep capillary plexus (DCP). Correlation analysis was used to analyze the relationship between LogMAR best-corrected visual acuity (BCVA) and quantitative parameters from OCTA. Results: Compared with NC eyes, the CMT and retinal thicknesses were increased significantly in eyes with uveitis (p < 0.05, respectively). No significant difference was observed in the FAZ area. FD300, VDs in the optic disk, SCP, and DCP both in whole image and parafovea, choriocapillaris were significantly decreased in uveitis eyes (p < 0.05, respectively) compared with NC eyes, only the acute group had decreased VD of the outer retina and choriocapillaris compared with the NC group (p < 0.05). Moreover, quantitative parameters of OCTA showed a significant correlation with LogMAR BCVA in the patients with uveitis. Whole VD DCP was the best predictive factor for BCVA in the patients with uveitis. Conclusion: Quantitative measurement by OCTA is a promising strategy for objective assessment of autoimmune posterior uveitis.
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DOI：
10.1186/s12348-017-0138-z
发表时间：
2017-10-05
影响因子：
2.9
作者：
Pichi F;Sarraf D;Morara M;Mazumdar S;Neri P;Gupta V
通讯作者：
Gupta V
DOI：
10.1097/iae.0000000000001255
发表时间：
2016-12-01
影响因子：
3.3
作者：
Pichi, Francesco;Srvivastava, Sunil K.;Sarraf, David
通讯作者：
Sarraf, David
DOI：
10.1097/iae.0000000000001412
发表时间：
2017-09-01
影响因子：
3.3
作者：
Mandadi, Spoorti Krishna Reddy;Agarwal, Aniruddha;Gupta, Vishali
通讯作者：
Gupta, Vishali
影响因子：
1.6
作者：
Cerquaglia, Alessio;Lupidi, Marco;Cagini, Carlo
通讯作者：
Cagini, Carlo
影响因子：
4.4
作者：
Popovic, Zoran;Knutsson, Per;Sjostrand, Johan
通讯作者：
Sjostrand, Johan