Associations between childhood chronic stress and dynamic functional connectivity in drug-naïve, first-episode adolescent MDD.
Associations between childhood chronic stress and dynamic functional connectivity in drug-naïve, first-episode adolescent MDD.
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儿童期慢性压力与初治青少年 MDD 动态功能连接之间的关联。
DOI：
10.1016/j.jad.2021.11.050
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发表时间：
2021-11
影响因子：
6.6
通讯作者：
Yin Li
中科院分区：
文献类型：
--
作者：
Zhang Hang;Tao Yuanmei;Xu Hanmei;Zou Shoukang;Deng Fang;Huang Lijuan;Zhang Hong;Wang Xiaolan;Tang Xiaowei;Dong Zaiquan;Wang Yanping;Fu Xia;Yin Li
背景我们利用未曾用药的初发重度抑郁症 (MDD) 青少年的静息态 MRI 数据，探讨了慢性压力与全脑动态工作模式之间的关联。方法我们比较了动态功能连接 (dyn-FC)，并使用动态独立成分分析筛选出 45 名健康对照 (HC) 和 60 名青少年 MDD 患者之间全脑存在差异的网络。在每个组间存在差异的网络中，中枢大脑区域被选择为同时与 30 多个大脑区域功能连接。然后提取每个中枢脑区与其他脑区在不同时间点的dyn-FC系数，并计算整个扫描时间的平均值。最后，我们探讨了整个扫描时间的平均值与儿童慢性应激问卷 (CCSQ) 分数之间的相关性。结果我们发现青少年 MDD 和 HC 之间的三个网络以及一些具有不同 dyn-FC 模式的中枢大脑区域。研究发现，CCSQ 得分与 MDD 患者的中枢大脑区域和某些其他大脑区域之间的动态 FC 相关。我们的横断面研究设计的局限性不允许我们推测慢性压力和抑郁之间的因果关系。前瞻性队列研究应详细探讨MDD期间动态FC的变化是如何出现和演变的。结论慢性压力与青少年MDD的大脑动态工作模式有关。
BackgroundWe explored the associations between chronic stress and dynamic working patterns of the whole brain using resting state MRI data in drug-naïve, first-episode adolescents with major depressive disorder (MDD).MethodsWe compared dynamic functional connectivity (dyn-FC) and screen out networks with difference in whole brain between 45 healthy controls (HC) and 60 adolescent MDD patients using dynamic independent components analysis. In each of these networks with difference between groups, hub brain regions were selected as functionally connected to more than 30 brain regions at the same time. Then we extracted the dyn-FC coefficients of each hub brain region with other brain regions in each component at different time points and calculated the average value of the entire scan time. Finally, we explored correlations between these average values of the entire scan time and scores on the Childhood Chronic Stress Questionnaire (CCSQ).ResultsWe found three networks as well as some hub brain regions with different dyn-FC patterns between adolescent MDD and HC. Scores on the CCSQ were found to correlate with dynamic FC between hub brain areas and certain other brain areas in MDD patients.Limitationsour cross-sectional study design does not allow us to speculate about causality between chronic stress and depression. Prospective cohort studies should explore in detail how the changes in dynamic FC appear and evolve during MDD.ConclusionsChronic stress is related with the brain dynamic working patterns in adolescent MDD.
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在重度抑郁症的工作记忆更新过程中，视觉皮质激活和与前额叶皮层的连通性改变了。
DOI：
10.1016/j.nicl.2017.01.004
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
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作者：
Le TM;Borghi JA;Kujawa AJ;Klein DN;Leung HC
通讯作者：
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影响因子：
4.6
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DOI：
10.1001/jama.2017.3826
发表时间：
2017-04-18
期刊：
JAMA
影响因子：
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作者：
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通讯作者：
Friedrich, M J
影响因子：
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作者：
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影响因子：
5.7
作者：
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通讯作者：
Griffiths, Timothy D.