Depression, anxiety, and quality of life in paroxysmal kinesigenic dyskinesia patients.
Depression, anxiety, and quality of life in paroxysmal kinesigenic dyskinesia patients.
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阵发性运动源性运动障碍患者的抑郁、焦虑和生活质量
DOI：
10.4103/0366-6999.213431
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发表时间：
2017-09-05
影响因子：
6.1
通讯作者：
Cao L
中科院分区：
文献类型：
--
作者：
Tian WT;Huang XJ;Liu XL;Shen JY;Liang GL;Zhu CX;Tang WG;Chen SD;Song YY;Cao L
阵发性动态性运动障碍（PKD）是一种罕见的运动障碍，其特征是由突然的自主运动引发的反复的张力障碍或舞蹈病样发作。在有心理负担的情况下，部分患者的发作会加重，持续时间更长，发作频率更高。本研究旨在评估大量PKD患者的非运动症状和生活质量。采用症状检查表90-修订版（SCL-90-R）、世界卫生组织生活质量量表（WHOQoL-100）、抑郁自评量表和焦虑自评量表对2008年8月至2016年10月在瑞金医院就诊的165例原发性PKD患者进行横断面调查。我们采用非配对学生t检验评估患者的SCL-90-R和WHOQOL-100评分与中国规范数据（来自文献）的差异。我们应用多元线性回归分析运动表现、心理健康和PKD患者生活质量之间的关系。与中国文献中获取的标准数据相比，PKD患者在所有SCL-90-R分量表（躯体化、强迫症、人际敏感、抑郁、焦虑、敌意、恐惧焦虑、偏执观念和精神病）上的得分均显著高于（低于）中国；WHOQoL-100的5个领域（身体领域、心理领域、独立领域、社会关系领域和一般生活质量）得分均显著降低（较差），P = 0.000。运动障碍发作未缓解（P = 0.011）和较高的抑郁评分（P = 0.000）与较低的生活质量水平显著相关。PKD患者抑郁和焦虑的发生率分别为41.2%（68/165）和26.7%（44/165）。抑郁、焦虑和低水平的生活质量在PKD患者中普遍存在。抑郁和焦虑的共存在这些患者中很常见。定期的心理健康干预可以将抑郁和焦虑作为干预目标。考虑到运动发作可由自主运动引起，有时也可由情绪压力引起，当患者处于压力状态时，症状可能会恶化，持续时间更长，频率更高，干预或治疗抑郁和焦虑可能会改善PKD患者的运动症状和整体生活质量。
Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder characterized by recurrent dystonic or choreoathetoid attacks triggered by sudden voluntary movements. Under the condition of psychological burden, some patients’ attacks may get worsened with longer duration and higher frequency. This study aimed to assess nonmotor symptoms and quality of life of patients with PKD in a large population. We performed a cross-sectional survey in 165 primary PKD patients from August 2008 to October 2016 in Rui Jin Hospital, using Symptom Check List-90-Revised (SCL-90-R), World Health Organization Quality of Life-100 (WHOQoL-100), Self-Rating Depression Scale, and Self-Rating Anxiety Scale. We evaluated the differences of SCL-90-R and WHOQOL-100 scores in patients and Chinese normative data (taken from literature) by using the unpaired Student's t-test. We applied multivariate linear regression to analyze the relationships between motor manifestations, mental health, and quality of life among PKD patients. Compared with Chinese normative data taken from literature, patients with PKD exhibited significantly higher (worse) scores across all SCL-90-R subscales (somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism; P = 0.000 for all) and significantly lower (worse) scores of five domains in WHOQoL-100 (physical domain, psychological domain, independence domain, social relationship domain, and general quality of life; P = 0.000 for all). Nonremission of dyskinesia episodes (P = 0.011) and higher depression score (P = 0.000) were significantly associated with lower levels of quality of life. The rates of depression and anxiety in patients with PKD were 41.2% (68/165) and 26.7% (44/165), respectively. Depression, anxiety, and low levels of quality of life were prevalent in patients with PKD. Co-occurrence of depression and anxiety was common among these patients. Regular mental health interventions could set depression and anxiety as intervention targets. Considering that the motor episodes could be elicited by voluntary movements and sometimes also by emotional stress, and that symptoms may get worsened with longer duration and higher frequency when patients are stressed out, intervention or treatment of depression and anxiety might improve the motor symptoms and overall quality of life in PKD patients.
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影响因子：
8.6
作者：
Hsu, Wan-Yu;Kwan, Shang-Yeong;Lin, Yung-Yang
通讯作者：
Lin, Yung-Yang
影响因子：
30.8
作者：
Chen, Wan-Jin;Lin, Yu;Wu, Zhi-Ying
通讯作者：
Wu, Zhi-Ying
影响因子：
5.4
作者：
Power, M;Kuyken, W;Sartorius, N
通讯作者：
Sartorius, N
影响因子：
9.9
作者：
Hsu, Wan-Yu;Liao, Kwong-Kum;Lin, Yung-Yang
通讯作者：
Lin, Yung-Yang
影响因子：
2.6
作者：
Szaflarski, JP;Szaflarski, M
通讯作者：
Szaflarski, M