MERS-CoV in Upper Respiratory Tract and Lungs of Dromedary Camels, Saudi Arabia, 2013-2014.

MERS-CoV in Upper Respiratory Tract and Lungs of Dromedary Camels, Saudi Arabia, 2013-2014.
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上呼吸道和肺部的肺部的MERS-COV,沙特阿拉伯,2013 - 2014年。

DOI:
10.3201/eid2107.150070
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发表时间:
2015-07
影响因子:
11.8
通讯作者:
Erdman DD
Erdman DD
中科院分区:
医学2区
文献类型:
--
作者:
Khalafalla AI;Lu X;Al-Mubarak AI;Dalab AH;Al-Busadah KA;Erdman DD

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证实了骆驼之间的广泛传播,特别是在较凉爽的月份。为了评估中东呼吸综合征冠状病毒(MERS-CoV)在单峰骆驼体内感染的时间动态,于2013年4月至2014年5月在沙特阿拉伯的Al-Ahsa省每隔1-2个月从两个独立的动物群体中采集样本,并用逆转录聚合酶链式反应(RT-PCR)检测MERS-CoV RNA。96头活骆驼中,28头(29.2%)鼻拭子阳性;91头骆驼身体中,56头(61.5%)肺组织标本阳性。阳性样本在幼年动物(4岁)中比成年动物(4岁)中更常见。两组阳性样本的比例因月而异;检测结果在2013年11月至2014年1月期间达到峰值,并在2014年3月和5月下降。这些发现进一步加深了我们对单峰骆驼MERS冠状病毒感染的理解,并可能有助于为减少人畜共患感染的干预策略提供参考。
Wide circulation among camels, especially during cooler months, is confirmed. To assess the temporal dynamics of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in dromedary camels, specimens were collected at 1–2 month intervals from 2 independent groups of animals during April 2013–May 2014 in Al-Ahsa Province, Saudi Arabia, and tested for MERS-CoV RNA by reverse transcription PCR. Of 96 live camels, 28 (29.2%) nasal swab samples were positive; of 91 camel carcasses, 56 (61.5%) lung tissue samples were positive. Positive samples were more commonly found among young animals (<4 years of age) than adults (>4 years of age). The proportions of positive samples varied by month for both groups; detection peaked during November 2013 and January 2014 and declined in March and May 2014. These findings further our understanding of MERS-CoV infection in dromedary camels and may help inform intervention strategies to reduce zoonotic infections.
DOI: 10.1093/tropej/44.2.100
发表时间: 1998-04-01
影响因子: 2
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