Norms for Clinical Use of CXM, a Real-Time Marker of Height Velocity.
Norms for Clinical Use of CXM, a Real-Time Marker of Height Velocity.
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DOI：
10.1210/clinem/dgaa721
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Horton WA
中科院分区：
文献类型：
--
作者：
Coghlan RF;Olney RC;Boston BA;Coleman DT;Johnstone B;Horton WA
高度速度（HV）很难评估，因为增长非常缓慢。目前的做法是每隔几个月进行一次测量来计算它，这不足以管理患有生长障碍的儿童。我们在健康儿童的血液中发现了一种骨骼生长副产物（胶原X生物标志物，CXM），在初步分析中，它与常规测定的HV密切相关，并显示出与已公布的HV随年龄变化的模式相似。目的是证实我们最初的观察结果，支持CXM作为HV生物标志物在更多个体中的效用，并为未来的研究建立工作参考范围。从302名健康儿童和10名健康成人的存档血液样本中评估CXM，得出961个CXM测量值。共有432个测量值按年龄绘制，并计算性别特定的参考范围。来自116名参与者的序列值根据观察到的HV绘制。比较匹配的血浆、血清和干血斑点读数。证实了血CXM与常规HV的相关性。CXM与年龄的散点图显示了与当前HV标准相似的模式，CXM水平划分了女孩和男孩的青春期生长突增。CXM水平在匹配的血清、血浆和干血斑样本中差异不大。血液CXM提供了一种实时估计HV的潜在手段。我们的研究结果为评估骨骼生长建立了性别特异性的、有效的参考范围，特别是随着时间的推移。CXM在储存样品中的稳定性使其非常适合于回顾性研究。
Height velocity (HV) is difficult to assess because growth is very slow. The current practice of calculating it from measurements taken at several-month intervals is insufficient for managing children with growth disorders. We identified a bone growth by-product (collagen X biomarker, CXM) in blood that in preliminary analysis in healthy children correlated strongly with conventionally determined HV and displayed a pattern resembling published norms for HV vs age. The goal was to confirm our initial observations supporting the utility of CXM as an HV biomarker in a larger number of individuals and establish working reference ranges for future studies. CXM was assessed in archived blood samples from 302 healthy children and 10 healthy adults yielding 961 CXM measurements. A total of 432 measurements were plotted by age, and sex-specific reference ranges were calculated. Serial values from 116 participants were plotted against observed HV. Matched plasma, serum, and dried blood spot readings were compared. A correlation of blood CXM with conventional HV was confirmed. Scatter plots of CXM vs age showed a similar pattern to current HV norms, and CXM levels demarcated the pubertal growth spurt both in girls and boys. CXM levels differed little in matched serum, plasma, and dried blood spot samples. Blood CXM offers a potential means to estimate HV in real time. Our results establish sex-specific, working reference ranges for assessing skeletal growth, especially over time. CXM stability in stored samples makes it well suited for retrospective studies.
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影响因子：
17.1
作者：
Coghlan RF;Oberdorf JA;Sienko S;Aiona MD;Boston BA;Connelly KJ;Bahney C;LaRouche J;Almubarak SM;Coleman DT;Girkontaite I;von der Mark K;Lunstrum GP;Horton WA
通讯作者：
Horton WA
影响因子：
5.2
作者：
TANNER, JM;WHITEHOUSE, RH
通讯作者：
WHITEHOUSE, RH
DOI：
10.1111/j.1467-9876.2005.00510.x
发表时间：
2005-01-01
影响因子：
1.6
作者：
Rigby, RA;Stasinopoulos, DM
通讯作者：
Stasinopoulos, DM
影响因子：
5.8
作者：
Kelly, Andrea;Winer, Karen K.;Zemel, Babette S.
通讯作者：
Zemel, Babette S.
C 型钠尿肽 (NTproCNP) 的氨基末端前肽可预测健康儿童的身高速度。
影响因子：
3.2
作者：
Olney RC;Permuy JW;Prickett TC;Han JC;Espiner EA
通讯作者：
Espiner EA